TY - INPR ID - discovery10203474 N2 - BACKGROUND: Optical coherence tomography (OCT) inner retinal metrics reflect neurodegeneration in multiple sclerosis (MS). We explored OCT measures as biomarkers of disease severity in secondary progressive MS (SPMS). METHODS: We investigated people with SPMS from the Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial OCT substudy, analysing brain MRIs, clinical assessments and OCT at baseline and 96 weeks. We measured peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses. Statistical analysis included correlations, multivariable linear regressions and mixed-effects models. RESULTS: Of the 212 participants recruited at baseline, 192 attended at 96 weeks follow-up. Baseline pRNFL and GCIPL thickness correlated with Symbol Digit Modalities Test (SDMT) (respectively, r=0.33 (95% CI 0.20 to 0.47); r=0.39 (0.26 to 0.51)) and deep grey matter volume (respectively, r=0.21 (0.07 to 0.35); r=0.28 (0.14 to 0.41)).pRNFL was associated with Expanded Disability Status Scale (EDSS) score change (normalised beta (B)=-0.12 (-0.23 to -0.01)). Baseline pRNFL and GCIPL were associated with Timed 25-Foot Walk change (T25FW) (respectively, B=-0.14 (-0.25 to -0.03); B=-0.20 (-0.31 to -0.10)) and 96-week percentage brain volume change (respectively, B=0.14 (0.03 to 0.25); B=0.23 (0.12 to 0.34)). There were significant annualised thinning rates: pRNFL (-0.83 µm/year) and GCIPL (-0.37 µm/year). CONCLUSIONS: In our cohort of people with SPMS and long disease duration, OCT measures correlated with SDMT and deep grey matter volume at baseline; EDSS, T25FW and whole brain volume change at follow-up. AV - public KW - Science & Technology KW - Life Sciences & Biomedicine KW - Clinical Neurology KW - Psychiatry KW - Surgery KW - Neurosciences & Neurology KW - MULTIPLE SCLEROSIS KW - IMAGE ANALYSIS KW - RANDOMISED TRIALS KW - NERVE-FIBER LAYER KW - DISABILITY KW - SEGMENTATION KW - THICKNESS KW - PATHOLOGY KW - ATROPHY KW - DRUGS KW - OCT Y1 - 2024/12/18/ A1 - De Angelis, Floriana A1 - Cameron, James R A1 - Eshaghi, Arman A1 - Parker, Richard A1 - Connick, Peter A1 - Stutters, Jonathan A1 - Plantone, Domenico A1 - Doshi, Anisha A1 - John, Nevin A1 - Williams, Thomas A1 - Calvi, Alberto A1 - Macmanus, David A1 - Barkhof, Frederik A1 - Chandran, Siddharthan A1 - Weir, Christopher J A1 - Toosy, Ahmed A1 - Chataway, Jeremy A1 - MS-SMART, Trial Investigators UR - https://doi.org/10.1136/jnnp-2024-334801 EP - 8 N1 - This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. TI - Optical coherence tomography in secondary progressive multiple sclerosis: cross-sectional and longitudinal exploratory analysis from the MS-SMART randomised controlled trial JF - Journal of Neurology, Neurosurgery and Psychiatry PB - BMJ PUBLISHING GROUP ER -