TY  - INPR
ID  - discovery10203474
N2  - BACKGROUND: Optical coherence tomography (OCT) inner retinal metrics reflect neurodegeneration in multiple sclerosis (MS). We explored OCT measures as biomarkers of disease severity in secondary progressive MS (SPMS). METHODS: We investigated people with SPMS from the Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial OCT substudy, analysing brain MRIs, clinical assessments and OCT at baseline and 96 weeks. We measured peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell-inner plexiform layer (GCIPL) thicknesses. Statistical analysis included correlations, multivariable linear regressions and mixed-effects models. RESULTS: Of the 212 participants recruited at baseline, 192 attended at 96 weeks follow-up. Baseline pRNFL and GCIPL thickness correlated with Symbol Digit Modalities Test (SDMT) (respectively, r=0.33 (95% CI 0.20 to 0.47); r=0.39 (0.26 to 0.51)) and deep grey matter volume (respectively, r=0.21 (0.07 to 0.35); r=0.28 (0.14 to 0.41)).pRNFL was associated with Expanded Disability Status Scale (EDSS) score change (normalised beta (B)=-0.12 (-0.23 to -0.01)). Baseline pRNFL and GCIPL were associated with Timed 25-Foot Walk change (T25FW) (respectively, B=-0.14 (-0.25 to -0.03); B=-0.20 (-0.31 to -0.10)) and 96-week percentage brain volume change (respectively, B=0.14 (0.03 to 0.25); B=0.23 (0.12 to 0.34)). There were significant annualised thinning rates: pRNFL (-0.83 µm/year) and GCIPL (-0.37 µm/year). CONCLUSIONS: In our cohort of people with SPMS and long disease duration, OCT measures correlated with SDMT and deep grey matter volume at baseline; EDSS, T25FW and whole brain volume change at follow-up.
AV  - public
KW  - Science & Technology
KW  -  Life Sciences & Biomedicine
KW  -  Clinical Neurology
KW  -  Psychiatry
KW  -  Surgery
KW  -  Neurosciences & Neurology
KW  -  MULTIPLE SCLEROSIS
KW  -  IMAGE ANALYSIS
KW  -  RANDOMISED TRIALS
KW  -  NERVE-FIBER LAYER
KW  -  DISABILITY
KW  -  SEGMENTATION
KW  -  THICKNESS
KW  -  PATHOLOGY
KW  -  ATROPHY
KW  -  DRUGS
KW  -  OCT
Y1  - 2024/12/18/
A1  - De Angelis, Floriana
A1  - Cameron, James R
A1  - Eshaghi, Arman
A1  - Parker, Richard
A1  - Connick, Peter
A1  - Stutters, Jonathan
A1  - Plantone, Domenico
A1  - Doshi, Anisha
A1  - John, Nevin
A1  - Williams, Thomas
A1  - Calvi, Alberto
A1  - Macmanus, David
A1  - Barkhof, Frederik
A1  - Chandran, Siddharthan
A1  - Weir, Christopher J
A1  - Toosy, Ahmed
A1  - Chataway, Jeremy
A1  - MS-SMART, Trial Investigators
UR  - https://doi.org/10.1136/jnnp-2024-334801
EP  - 8
N1  - This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
TI  - Optical coherence tomography in secondary progressive multiple sclerosis: cross-sectional and longitudinal exploratory analysis from the MS-SMART randomised controlled trial
JF  - Journal of Neurology, Neurosurgery and Psychiatry
PB  - BMJ PUBLISHING GROUP
ER  -