eprintid: 10203041 rev_number: 10 eprint_status: archive userid: 699 dir: disk0/10/20/30/41 datestamp: 2025-01-08 08:48:08 lastmod: 2025-01-08 08:54:49 status_changed: 2025-01-08 08:48:08 type: article metadata_visibility: show sword_depositor: 699 creators_name: Bartrés-Faz, David creators_name: Demnitz-King, Harriet creators_name: Cabello-Toscano, María creators_name: Vaqué-Alcázar, Lídia creators_name: Saunders, Rob creators_name: Touron, Edelweiss creators_name: Cattaneo, Gabriele creators_name: Gonneaud, Julie creators_name: Klimecki, Olga creators_name: Bargalló, Núria creators_name: Sánchez-Solana, Javier creators_name: Tormos, José M creators_name: Chételat, Gäel creators_name: Pascual-Leone, Álvaro creators_name: Marchant, Natalie L creators_name: André, Claire creators_name: Bachelet, Romain creators_name: Baez Lugo, Sebastian creators_name: Chocat, Anne creators_name: Collette, Fabienne creators_name: Coll-Padros, Nina creators_name: Dautricourt, Sophie creators_name: De La Sayette, Vincent creators_name: Delarue, Marion creators_name: Ferrand Devouge, Eglantine creators_name: Frison, Eric creators_name: Goldet, Karine creators_name: Jessen, Frank creators_name: Krolak-Salmon, Pierre creators_name: Kuhn, Elizabeth creators_name: Landeau, Brigitte creators_name: Lefranc, Valérie creators_name: Lutz, Antoine creators_name: Mezenge, Florence creators_name: Meiberth, Dix creators_name: Michel, Laurence creators_name: Molinuevo, José Luis creators_name: Ourry, Valentin creators_name: Poisnel, Géraldine creators_name: Quillard, Anne creators_name: Rauchs, Géraldine creators_name: Salmon, Eric creators_name: Schild, Ann-Katrin creators_name: Schimmer, Corinne creators_name: Smagghe, Delphine creators_name: Smith, Rhonda creators_name: Schlosser, Marco creators_name: Vuilleumier, Patrik creators_name: Wallet, Cédrick creators_name: Walker, Zuzana creators_name: Whitfield, Tim creators_name: Wirth, Miranka creators_name: The Medit-Ageing Research Group, title: Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults ispublished: inpress divisions: UCL divisions: B02 divisions: C07 divisions: D79 divisions: FH5 note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. abstract: Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 ± 7.0 years (mean ± s.d.); N = 750) and older adult (71.1 ± 5.9 years; N = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies. date: 2025-01-02 date_type: published publisher: Springer Science and Business Media LLC official_url: https://doi.org/10.1038/s44220-024-00361-8 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2346443 doi: 10.1038/s44220-024-00361-8 lyricists_name: Demnitz-King, Harriet lyricists_name: Marchant, Natalie lyricists_id: HCMDE73 lyricists_id: NLMAR24 actors_name: Marchant, Natalie actors_id: NLMAR24 actors_role: owner full_text_status: public publication: Nature Mental Health issn: 2731-6076 citation: Bartrés-Faz, David; Demnitz-King, Harriet; Cabello-Toscano, María; Vaqué-Alcázar, Lídia; Saunders, Rob; Touron, Edelweiss; Cattaneo, Gabriele; ... The Medit-Ageing Research Group; + view all <#> Bartrés-Faz, David; Demnitz-King, Harriet; Cabello-Toscano, María; Vaqué-Alcázar, Lídia; Saunders, Rob; Touron, Edelweiss; Cattaneo, Gabriele; Gonneaud, Julie; Klimecki, Olga; Bargalló, Núria; Sánchez-Solana, Javier; Tormos, José M; Chételat, Gäel; Pascual-Leone, Álvaro; Marchant, Natalie L; André, Claire; Bachelet, Romain; Baez Lugo, Sebastian; Chocat, Anne; Collette, Fabienne; Coll-Padros, Nina; Dautricourt, Sophie; De La Sayette, Vincent; Delarue, Marion; Ferrand Devouge, Eglantine; Frison, Eric; Goldet, Karine; Jessen, Frank; Krolak-Salmon, Pierre; Kuhn, Elizabeth; Landeau, Brigitte; Lefranc, Valérie; Lutz, Antoine; Mezenge, Florence; Meiberth, Dix; Michel, Laurence; Molinuevo, José Luis; Ourry, Valentin; Poisnel, Géraldine; Quillard, Anne; Rauchs, Géraldine; Salmon, Eric; Schild, Ann-Katrin; Schimmer, Corinne; Smagghe, Delphine; Smith, Rhonda; Schlosser, Marco; Vuilleumier, Patrik; Wallet, Cédrick; Walker, Zuzana; Whitfield, Tim; Wirth, Miranka; The Medit-Ageing Research Group; - view fewer <#> (2025) Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults. Nature Mental Health 10.1038/s44220-024-00361-8 <https://doi.org/10.1038/s44220-024-00361-8>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10203041/1/s44220-024-00361-8.pdf