TY  - INPR
A1  - Bartrés-Faz, David
A1  - Demnitz-King, Harriet
A1  - Cabello-Toscano, María
A1  - Vaqué-Alcázar, Lídia
A1  - Saunders, Rob
A1  - Touron, Edelweiss
A1  - Cattaneo, Gabriele
A1  - Gonneaud, Julie
A1  - Klimecki, Olga
A1  - Bargalló, Núria
A1  - Sánchez-Solana, Javier
A1  - Tormos, José M
A1  - Chételat, Gäel
A1  - Pascual-Leone, Álvaro
A1  - Marchant, Natalie L
A1  - André, Claire
A1  - Bachelet, Romain
A1  - Baez Lugo, Sebastian
A1  - Chocat, Anne
A1  - Collette, Fabienne
A1  - Coll-Padros, Nina
A1  - Dautricourt, Sophie
A1  - De La Sayette, Vincent
A1  - Delarue, Marion
A1  - Ferrand Devouge, Eglantine
A1  - Frison, Eric
A1  - Goldet, Karine
A1  - Jessen, Frank
A1  - Krolak-Salmon, Pierre
A1  - Kuhn, Elizabeth
A1  - Landeau, Brigitte
A1  - Lefranc, Valérie
A1  - Lutz, Antoine
A1  - Mezenge, Florence
A1  - Meiberth, Dix
A1  - Michel, Laurence
A1  - Molinuevo, José Luis
A1  - Ourry, Valentin
A1  - Poisnel, Géraldine
A1  - Quillard, Anne
A1  - Rauchs, Géraldine
A1  - Salmon, Eric
A1  - Schild, Ann-Katrin
A1  - Schimmer, Corinne
A1  - Smagghe, Delphine
A1  - Smith, Rhonda
A1  - Schlosser, Marco
A1  - Vuilleumier, Patrik
A1  - Wallet, Cédrick
A1  - Walker, Zuzana
A1  - Whitfield, Tim
A1  - Wirth, Miranka
A1  - The Medit-Ageing Research Group
JF  - Nature Mental Health
SN  - 2731-6076
PB  - Springer Science and Business Media LLC
UR  - https://doi.org/10.1038/s44220-024-00361-8
ID  - discovery10203041
N2  - Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 ± 7.0 years (mean ± s.d.); N?=?750) and older adult (71.1 ± 5.9 years; N?=?282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies.
N1  - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article?s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article?s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
AV  - public
Y1  - 2025/01/02/
TI  - Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults
ER  -