@article{discovery10203041,
            year = {2025},
         journal = {Nature Mental Health},
       publisher = {Springer Science and Business Media LLC},
           title = {Psychological profiles associated with mental, cognitive and brain health in middle-aged and older adults},
            note = {This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.},
           month = {January},
            issn = {2731-6076},
             url = {https://doi.org/10.1038/s44220-024-00361-8},
        abstract = {Psychological characteristics are associated with varying dementia risk and protective factors. To determine whether these characteristics aggregate into psychological profiles and whether these profiles differentially relate to aging health, we conducted a cross-sectional investigation in two independent middle-aged (51.4 {$\pm$} 7.0 years (mean {$\pm$} s.d.); N = 750) and older adult (71.1 {$\pm$} 5.9 years; N = 282) cohorts, supplemented by longitudinal analyses in the former. Using a person-centered approach, three profiles emerged in both cohorts: those with low protective characteristics (profile 1), high risk characteristics (profile 2) and well-balanced characteristics (profile 3). Profile 1 showed the worst objective cognition in older age and middle age (at follow-up), and most rapid cortical thinning. Profile 2 exhibited the worst mental health symptomology and lowest sleep quality in both older age and middle age. We identified profile-dependent divergent patterns of associations that may suggest two distinct paths for mental, cognitive and brain health, emphasizing the need for comprehensive psychological assessments in dementia prevention research to identify groups for more personalized behavior-change strategies.},
          author = {Bartr{\'e}s-Faz, David and Demnitz-King, Harriet and Cabello-Toscano, Mar{\'i}a and Vaqu{\'e}-Alc{\'a}zar, L{\'i}dia and Saunders, Rob and Touron, Edelweiss and Cattaneo, Gabriele and Gonneaud, Julie and Klimecki, Olga and Bargall{\'o}, N{\'u}ria and S{\'a}nchez-Solana, Javier and Tormos, Jos{\'e} M and Ch{\'e}telat, G{\"a}el and Pascual-Leone, {\'A}lvaro and Marchant, Natalie L and Andr{\'e}, Claire and Bachelet, Romain and Baez Lugo, Sebastian and Chocat, Anne and Collette, Fabienne and Coll-Padros, Nina and Dautricourt, Sophie and De La Sayette, Vincent and Delarue, Marion and Ferrand Devouge, Eglantine and Frison, Eric and Goldet, Karine and Jessen, Frank and Krolak-Salmon, Pierre and Kuhn, Elizabeth and Landeau, Brigitte and Lefranc, Val{\'e}rie and Lutz, Antoine and Mezenge, Florence and Meiberth, Dix and Michel, Laurence and Molinuevo, Jos{\'e} Luis and Ourry, Valentin and Poisnel, G{\'e}raldine and Quillard, Anne and Rauchs, G{\'e}raldine and Salmon, Eric and Schild, Ann-Katrin and Schimmer, Corinne and Smagghe, Delphine and Smith, Rhonda and Schlosser, Marco and Vuilleumier, Patrik and Wallet, C{\'e}drick and Walker, Zuzana and Whitfield, Tim and Wirth, Miranka and The Medit-Ageing Research Group, {}}
}