eprintid: 10202983
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/20/29/83
datestamp: 2025-01-07 16:19:11
lastmod: 2025-01-07 16:19:11
status_changed: 2025-01-07 16:19:11
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Codd, V
creators_name: Denniff, M
creators_name: Swinfield, C
creators_name: Warner, SC
creators_name: Papakonstantinou, M
creators_name: Sheth, S
creators_name: Nanus, DE
creators_name: Budgeon, CA
creators_name: Musicha, C
creators_name: Bountziouka, V
creators_name: Wang, Q
creators_name: Bramley, R
creators_name: Allara, E
creators_name: Kaptoge, S
creators_name: Stoma, S
creators_name: Jiang, T
creators_name: Butterworth, AS
creators_name: Wood, AM
creators_name: Di Angelantonio, E
creators_name: Thompson, JR
creators_name: Danesh, JN
creators_name: Nelson, CP
creators_name: Samani, NJ
title: Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G25
keywords: Predictive markers
note: This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We confirm that older age and male sex associate with shorter LTL, with women on average ~7 years younger in 'biological age' than men. Compared to white Europeans, LTL is markedly longer in African and Chinese ancestries. Older paternal age at birth is associated with longer individual LTL. Higher white cell count is associated with shorter LTL, but proportions of white cell subtypes show weaker associations. Age, ethnicity, sex and white cell count explain ~5.5% of LTL variance. Using paired samples from 1,351 participants taken ~5 years apart, we estimate the within-individual variability in LTL and provide a correction factor for this. This resource provides opportunities to investigate determinants and biomedical consequences of variation in LTL.
date: 2022-02-17
date_type: published
publisher: SPRINGERNATURE
official_url: https://doi.org/10.1038/s43587-021-00166-9
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2019316
doi: 10.1038/s43587-021-00166-9
medium: Print-Electronic
pii: 10.1038/s43587-021-00166-9
lyricists_name: Bountziouka, Vasiliki
lyricists_id: VBOUN85
actors_name: Bountziouka, Vasiliki
actors_id: VBOUN85
actors_role: owner
funding_acknowledgements: [UK Medical Research Council (MRC)]; [Biotechnology and Biological Sciences Research Council]; MR/M012816/1 [British Heart Foundation (BHF) through MRC grant]; SP/16/4/32697 [BHF]; RG/13/13/30194 [BHF]; RG/18/13/33946 [BHF]; CH/12/2/29428 [BHF]; MR/L003120/1 [MRC]; BRC-1215-20010 [National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Centre]; BRC-1215-20014 [NIHR Cambridge Biomedical Research Centre]; NIHR BTRU-2014-10024 [NIHR Blood and Transplant Research Unit in Donor Health and Genomics]; [Health Data Research UK]; 11607 [EU/EFPIA Innovative Medicines Initiative Joint Undertaking BigData@Heart]; [van Geest Heart and Cardiovascular Diseases Research Fund, University of Leicester]; MR/M012816/1 [MRC]; MR/L003120/1 [MRC]
full_text_status: public
publication: Nature Aging
volume: 2
pagerange: 170-179
pages: 23
event_location: United States
issn: 2662-8465
citation:        Codd, V;    Denniff, M;    Swinfield, C;    Warner, SC;    Papakonstantinou, M;    Sheth, S;    Nanus, DE;                                                                 ... Samani, NJ; + view all <#>        Codd, V;  Denniff, M;  Swinfield, C;  Warner, SC;  Papakonstantinou, M;  Sheth, S;  Nanus, DE;  Budgeon, CA;  Musicha, C;  Bountziouka, V;  Wang, Q;  Bramley, R;  Allara, E;  Kaptoge, S;  Stoma, S;  Jiang, T;  Butterworth, AS;  Wood, AM;  Di Angelantonio, E;  Thompson, JR;  Danesh, JN;  Nelson, CP;  Samani, NJ;   - view fewer <#>    (2022)    Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank.                   Nature Aging , 2    pp. 170-179.    10.1038/s43587-021-00166-9 <https://doi.org/10.1038/s43587-021-00166-9>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10202983/1/Bountziouka_P093_Codd%20et%20al_LTL%20characterisation_Nat%20Aging%202022_AAM.pdf