<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10202782> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/title> "Biological hallmarks of systemic sclerosis are present in the skin and serum of patients with Very Early Diagnosis of SSc (VEDOSS)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/abstract> "OBJECTIVE: The Very Early Diagnosis of Systemic Sclerosis (VEDOSS) EUSTAR study showed that, despite not showing any clinical sign of disease, patients with Raynaud's and antinuclear antibodies and/or capillaroscopy abnormalities often progress to systemic sclerosis (SSc) within 5 years. We aimed to determine whether VEDOSS biosamples show biological SSc activity pre-clinically. METHODS: Skin biopsies were histologically analysed. Dermal fibroblasts analysed by RT-qPCR and gel contraction assays. Sera were assayed by Luminex (CXCL10) or ELISA (ELF score). Healthy controls (HC) and SSc biosamples were used for controls. RESULTS: Overall, 114 consecutive VEDOSS patients were enrolled, of which 36 consented to have skin biopsies. Skin biopsies showed a variable but overall increased collagen staining and skin thickness, increased perivascular infiltrate of CD45 positive cells and CXCL10 expression. In vitro, VEDOSS dermal fibroblasts showed increased profibrotic gene expression and contractibility compared with HC. Increased serological CXCL10 (mean [SD]; 75.90 [107.80] vs HC 39.90 [26.27] pg/ml, p = 0.02) and ELF score was evident in VEDOSS compared with HC (8.19 [0.78] vs 8.55 [0.79], p = 0.04). In longitudinal analysis of a median of 27.5 (IQR 44.5) months, 14.9% of VEDOSS patients progressed to SSc. Baseline CXCL10 serum concentration was significantly higher in the VEDOSS patients that progressed (2-fold increase, p = 0.0071) and correlated with ELF score (R = 0.3096, p = 0.0065). CONCLUSIONS: Despite not fulfilling classification criteria, VEDOSS patients show SSc-linked fibrosis and immunity dysregulation both within the tissue and sera, supporting a biological diagnosis of disease and a window of opportunity to detect the biological pathways amenable for preventive intervention."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/date> "2024-12-19" .
<https://discovery.ucl.ac.uk/id/document/1813183> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/org/ext-daeb92daf570917684167066877da0ed> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-daeb92daf570917684167066877da0ed> <http://xmlns.com/foaf/0.1/name> "Oxford University Press (OUP)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-daeb92daf570917684167066877da0ed> .
<https://discovery.ucl.ac.uk/id/publication/ext-14620324> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-14620324> <http://xmlns.com/foaf/0.1/name> "Rheumatology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-14620324> .
<https://discovery.ucl.ac.uk/id/publication/ext-14620324> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:14620324> .
<https://discovery.ucl.ac.uk/id/publication/ext-14620324> <http://purl.org/ontology/bibo/issn> "14620324" .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/forthcoming> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bcf3ae89e76da214d5539abf112f0d66> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-bcf3ae89e76da214d5539abf112f0d66> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-834f1f0ed958c5c104d27072464d4f6f> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-834f1f0ed958c5c104d27072464d4f6f> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e5330c3331eb3c1fcd0c0835ccb3471b> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-e5330c3331eb3c1fcd0c0835ccb3471b> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e9d39ea55504671614876547a0d2dfbc> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e9d39ea55504671614876547a0d2dfbc> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ee844bf74d7e02cc59c16e5ab744d738> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-ee844bf74d7e02cc59c16e5ab744d738> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0281c9bc8d4aedf09cedb4b05580a698> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-0281c9bc8d4aedf09cedb4b05580a698> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1c28adf2484ed1a18349769c7cc740a1> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-1c28adf2484ed1a18349769c7cc740a1> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5938aeef993a2d2dfb9506b8ecce27cb> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-5938aeef993a2d2dfb9506b8ecce27cb> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-28e83a8e813d845c21b7552f156cfb16> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-28e83a8e813d845c21b7552f156cfb16> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5f4a2c93eff28afd9faab4620f345263> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-5f4a2c93eff28afd9faab4620f345263> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4d1ebbc16dce9b7b2664380c59043ae3> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-4d1ebbc16dce9b7b2664380c59043ae3> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f0a12c3b5b0841ea1935dc42f7193059> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-f0a12c3b5b0841ea1935dc42f7193059> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-10a735f6cd745a9f29d614c6e9860d0f> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-10a735f6cd745a9f29d614c6e9860d0f> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-20a70e9ba9e8cf086b152d73a9883b08> .
<https://discovery.ucl.ac.uk/id/eprint/10202782> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202782#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202782#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-20a70e9ba9e8cf086b152d73a9883b08> .
<https://discovery.ucl.ac.uk/id/person/ext-5938aeef993a2d2dfb9506b8ecce27cb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5938aeef993a2d2dfb9506b8ecce27cb> <http://xmlns.com/foaf/0.1/givenName> "Will"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5938aeef993a2d2dfb9506b8ecce27cb> <http://xmlns.com/foaf/0.1/familyName> "Merchant"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5938aeef993a2d2dfb9506b8ecce27cb> <http://xmlns.com/foaf/0.1/name> "Will Merchant"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-20a70e9ba9e8cf086b152d73a9883b08> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-20a70e9ba9e8cf086b152d73a9883b08> <http://xmlns.com/foaf/0.1/givenName> "Francesco"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-20a70e9ba9e8cf086b152d73a9883b08> <http://xmlns.com/foaf/0.1/familyName> "Del Galdo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-20a70e9ba9e8cf086b152d73a9883b08> <http://xmlns.com/foaf/0.1/name> "Francesco Del Galdo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28e83a8e813d845c21b7552f156cfb16> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-28e83a8e813d845c21b7552f156cfb16> <http://xmlns.com/foaf/0.1/givenName> "Stefano"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28e83a8e813d845c21b7552f156cfb16> <http://xmlns.com/foaf/0.1/familyName> "Di Donato"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28e83a8e813d845c21b7552f156cfb16> <http://xmlns.com/foaf/0.1/name> "Stefano Di Donato"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ee844bf74d7e02cc59c16e5ab744d738> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ee844bf74d7e02cc59c16e5ab744d738> <http://xmlns.com/foaf/0.1/givenName> "Christopher W"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ee844bf74d7e02cc59c16e5ab744d738> <http://xmlns.com/foaf/0.1/familyName> "Wasson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ee844bf74d7e02cc59c16e5ab744d738> <http://xmlns.com/foaf/0.1/name> "Christopher W Wasson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e5330c3331eb3c1fcd0c0835ccb3471b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e5330c3331eb3c1fcd0c0835ccb3471b> <http://xmlns.com/foaf/0.1/givenName> "Emily L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e5330c3331eb3c1fcd0c0835ccb3471b> <http://xmlns.com/foaf/0.1/familyName> "Clarke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e5330c3331eb3c1fcd0c0835ccb3471b> <http://xmlns.com/foaf/0.1/name> "Emily L Clarke"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bcf3ae89e76da214d5539abf112f0d66> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-bcf3ae89e76da214d5539abf112f0d66> <http://xmlns.com/foaf/0.1/givenName> "Rebecca L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bcf3ae89e76da214d5539abf112f0d66> <http://xmlns.com/foaf/0.1/familyName> "Ross"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-bcf3ae89e76da214d5539abf112f0d66> <http://xmlns.com/foaf/0.1/name> "Rebecca L Ross"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10a735f6cd745a9f29d614c6e9860d0f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-10a735f6cd745a9f29d614c6e9860d0f> <http://xmlns.com/foaf/0.1/givenName> "Natalia A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10a735f6cd745a9f29d614c6e9860d0f> <http://xmlns.com/foaf/0.1/familyName> "Riobo-Del Galdo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10a735f6cd745a9f29d614c6e9860d0f> <http://xmlns.com/foaf/0.1/name> "Natalia A Riobo-Del Galdo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5f4a2c93eff28afd9faab4620f345263> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5f4a2c93eff28afd9faab4620f345263> <http://xmlns.com/foaf/0.1/givenName> "Andrea"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5f4a2c93eff28afd9faab4620f345263> <http://xmlns.com/foaf/0.1/familyName> "Rindone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5f4a2c93eff28afd9faab4620f345263> <http://xmlns.com/foaf/0.1/name> "Andrea Rindone"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0281c9bc8d4aedf09cedb4b05580a698> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0281c9bc8d4aedf09cedb4b05580a698> <http://xmlns.com/foaf/0.1/givenName> "Panji"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0281c9bc8d4aedf09cedb4b05580a698> <http://xmlns.com/foaf/0.1/familyName> "Mulipa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0281c9bc8d4aedf09cedb4b05580a698> <http://xmlns.com/foaf/0.1/name> "Panji Mulipa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f0a12c3b5b0841ea1935dc42f7193059> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f0a12c3b5b0841ea1935dc42f7193059> <http://xmlns.com/foaf/0.1/givenName> "Christopher P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f0a12c3b5b0841ea1935dc42f7193059> <http://xmlns.com/foaf/0.1/familyName> "Denton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f0a12c3b5b0841ea1935dc42f7193059> <http://xmlns.com/foaf/0.1/name> "Christopher P Denton"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4d1ebbc16dce9b7b2664380c59043ae3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
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