<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10202708> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/title> "Type I interferon and mitochondrial dysfunction are associated with dysregulated cytotoxic CD8+ T cell responses in juvenile systemic lupus erythematosus"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/abstract> "Juvenile systemic lupus erythematosus (JSLE) is an autoimmune condition which causes significant morbidity in children and young adults and is more severe in its presentation than adult-onset SLE. While many aspects of immune dysfunction have been studied extensively in adult-onset SLE, there is limited and contradictory evidence of how cytotoxic CD8+ T cells contribute to disease pathogenesis and studies exploring cytotoxicity in JSLE are virtually non-existent. Here, we report that CD8+ T cell cytotoxic capacity is reduced in JSLE versus healthy controls, irrespective of treatment or disease activity. Transcriptomic and serum metabolomic analysis identified that this reduction in cytotoxic CD8+ T cells in JSLE was associated with upregulated type I interferon (IFN) signalling, mitochondrial dysfunction, and metabolic disturbances when compared to controls. Greater interrogation of the influence of these pathways on altered cytotoxic CD8+ T cell function demonstrated that JSLE CD8+ T cells had enlarged mitochondria and enhanced sensitivity to IFN-α leading to selective apoptosis of effector memory (EM) CD8+ T cells, which are enriched for cytotoxic mediator-expressing cells. This process ultimately contributes to the observed reduction in CD8+ T cell cytotoxicity in JSLE, reinforcing the growing evidence that mitochondrial dysfunction is a key pathogenic factor affecting multiple immune cell populations in type I IFN-driven rheumatic diseases."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/date> "2025-12-25" .
<https://discovery.ucl.ac.uk/id/document/1813101> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/publication/ext-6ca3d75d5b11a46908b9c6ef18e900f7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-6ca3d75d5b11a46908b9c6ef18e900f7> <http://xmlns.com/foaf/0.1/name> "Clinical and Experimental Immunology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-6ca3d75d5b11a46908b9c6ef18e900f7> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/forthcoming> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-34dcf53850aec316426363aedf2b0ca4> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-34dcf53850aec316426363aedf2b0ca4> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eedc6b931a2cd6b9a86b9ba673bff08d> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-eedc6b931a2cd6b9a86b9ba673bff08d> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ffbd8bc6d1a1952f08a9fc2bd5f3b463> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-ffbd8bc6d1a1952f08a9fc2bd5f3b463> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-587822715cfafca1122197609422de54> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-587822715cfafca1122197609422de54> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dbc63a599322fc1dc76c9ada0449f5bf> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-dbc63a599322fc1dc76c9ada0449f5bf> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d93515f6158c2b5368e2d361be725718> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-d93515f6158c2b5368e2d361be725718> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7c26faca2ac043b6d2241f2066b759ba> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-7c26faca2ac043b6d2241f2066b759ba> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2408509e5663c88e8baa02c33039ef13> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-2408509e5663c88e8baa02c33039ef13> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7f5519aefa2776595dd0f5fefe96f41c> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-7f5519aefa2776595dd0f5fefe96f41c> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e81a9656540aa7045336238c8515a679> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-e81a9656540aa7045336238c8515a679> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a1bd3a9eb15d55dde67586b8276fa826> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-a1bd3a9eb15d55dde67586b8276fa826> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-de7229aa892998e3fc50092e9c36348d> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-de7229aa892998e3fc50092e9c36348d> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b1e943278f216675b7ffeeb662e5ba98> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-b1e943278f216675b7ffeeb662e5ba98> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b24d55a2dfe102d693a759354e9e9478> .
<https://discovery.ucl.ac.uk/id/eprint/10202708> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10202708#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10202708#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-b24d55a2dfe102d693a759354e9e9478> .
<https://discovery.ucl.ac.uk/id/person/ext-587822715cfafca1122197609422de54> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-587822715cfafca1122197609422de54> <http://xmlns.com/foaf/0.1/givenName> "Melissa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-587822715cfafca1122197609422de54> <http://xmlns.com/foaf/0.1/familyName> "Kartawinata"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-587822715cfafca1122197609422de54> <http://xmlns.com/foaf/0.1/name> "Melissa Kartawinata"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ffbd8bc6d1a1952f08a9fc2bd5f3b463> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ffbd8bc6d1a1952f08a9fc2bd5f3b463> <http://xmlns.com/foaf/0.1/givenName> "Restuadi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ffbd8bc6d1a1952f08a9fc2bd5f3b463> <http://xmlns.com/foaf/0.1/familyName> "Restuadi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ffbd8bc6d1a1952f08a9fc2bd5f3b463> <http://xmlns.com/foaf/0.1/name> "Restuadi Restuadi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eedc6b931a2cd6b9a86b9ba673bff08d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-eedc6b931a2cd6b9a86b9ba673bff08d> <http://xmlns.com/foaf/0.1/givenName> "Hannah"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eedc6b931a2cd6b9a86b9ba673bff08d> <http://xmlns.com/foaf/0.1/familyName> "Peckham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eedc6b931a2cd6b9a86b9ba673bff08d> <http://xmlns.com/foaf/0.1/name> "Hannah Peckham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b1e943278f216675b7ffeeb662e5ba98> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b1e943278f216675b7ffeeb662e5ba98> <http://xmlns.com/foaf/0.1/givenName> "Elizabeth"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b1e943278f216675b7ffeeb662e5ba98> <http://xmlns.com/foaf/0.1/familyName> "Rosser"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b1e943278f216675b7ffeeb662e5ba98> <http://xmlns.com/foaf/0.1/name> "Elizabeth Rosser"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1bd3a9eb15d55dde67586b8276fa826> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a1bd3a9eb15d55dde67586b8276fa826> <http://xmlns.com/foaf/0.1/givenName> "Lucy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1bd3a9eb15d55dde67586b8276fa826> <http://xmlns.com/foaf/0.1/familyName> "Wedderburn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a1bd3a9eb15d55dde67586b8276fa826> <http://xmlns.com/foaf/0.1/name> "Lucy Wedderburn"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e81a9656540aa7045336238c8515a679> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e81a9656540aa7045336238c8515a679> <http://xmlns.com/foaf/0.1/givenName> "Meredyth"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e81a9656540aa7045336238c8515a679> <http://xmlns.com/foaf/0.1/familyName> "Wilkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e81a9656540aa7045336238c8515a679> <http://xmlns.com/foaf/0.1/name> "Meredyth Wilkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b24d55a2dfe102d693a759354e9e9478> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b24d55a2dfe102d693a759354e9e9478> <http://xmlns.com/foaf/0.1/givenName> "Coziana"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b24d55a2dfe102d693a759354e9e9478> <http://xmlns.com/foaf/0.1/familyName> "Ciurtin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b24d55a2dfe102d693a759354e9e9478> <http://xmlns.com/foaf/0.1/name> "Coziana Ciurtin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7f5519aefa2776595dd0f5fefe96f41c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7f5519aefa2776595dd0f5fefe96f41c> <http://xmlns.com/foaf/0.1/givenName> "Claire"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7f5519aefa2776595dd0f5fefe96f41c> <http://xmlns.com/foaf/0.1/familyName> "Deakin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7f5519aefa2776595dd0f5fefe96f41c> <http://xmlns.com/foaf/0.1/name> "Claire Deakin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dbc63a599322fc1dc76c9ada0449f5bf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dbc63a599322fc1dc76c9ada0449f5bf> <http://xmlns.com/foaf/0.1/givenName> "Dale"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dbc63a599322fc1dc76c9ada0449f5bf> <http://xmlns.com/foaf/0.1/familyName> "Moulding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dbc63a599322fc1dc76c9ada0449f5bf> <http://xmlns.com/foaf/0.1/name> "Dale Moulding"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7c26faca2ac043b6d2241f2066b759ba> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7c26faca2ac043b6d2241f2066b759ba> <http://xmlns.com/foaf/0.1/givenName> "George A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7c26faca2ac043b6d2241f2066b759ba> <http://xmlns.com/foaf/0.1/familyName> "Robinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7c26faca2ac043b6d2241f2066b759ba> <http://xmlns.com/foaf/0.1/name> "George A Robinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de7229aa892998e3fc50092e9c36348d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-de7229aa892998e3fc50092e9c36348d> <http://xmlns.com/foaf/0.1/givenName> "Elizabeth"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de7229aa892998e3fc50092e9c36348d> <http://xmlns.com/foaf/0.1/familyName> "Jury"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de7229aa892998e3fc50092e9c36348d> <http://xmlns.com/foaf/0.1/name> "Elizabeth Jury"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2408509e5663c88e8baa02c33039ef13> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2408509e5663c88e8baa02c33039ef13> <http://xmlns.com/foaf/0.1/givenName> "Maryam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2408509e5663c88e8baa02c33039ef13> <http://xmlns.com/foaf/0.1/familyName> "Butt"^^<http://www.w3.org/2001/XMLSchema#string> .
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