eprintid: 10201497 rev_number: 8 eprint_status: archive userid: 699 dir: disk0/10/20/14/97 datestamp: 2024-12-12 11:37:34 lastmod: 2024-12-12 11:37:34 status_changed: 2024-12-12 11:37:34 type: article metadata_visibility: show sword_depositor: 699 creators_name: Arab, Juan Pablo creators_name: Díaz, Luis Antonio creators_name: Rehm, Jürgen creators_name: Im, Gene creators_name: Arrese, Marco creators_name: Kamath, Patrick S creators_name: Lucey, Michael R creators_name: Mellinger, Jessica creators_name: Thiele, Maja creators_name: Thursz, Mark creators_name: Bataller, Ramon creators_name: Burton, Robyn creators_name: Chokshi, Shilpa creators_name: Francque, Sven M creators_name: Krag, Aleksander creators_name: Lackner, Carolin creators_name: Lee, Brian P creators_name: Liangpunsakul, Suthat creators_name: MacClain, Craig creators_name: Mandrekar, Pranoti creators_name: Mitchell, Mack C creators_name: Morgan, Marsha Y creators_name: Morgan, Timothy R creators_name: Pose, Elisa creators_name: Shah, Vijay H creators_name: Shawcross, Debbie creators_name: Sheron, Nick creators_name: Singal, Ashwani K creators_name: Stefanescu, Horia creators_name: Terrault, Norah creators_name: Trépo, Eric creators_name: Moreno, Christophe creators_name: Louvet, Alexandre creators_name: Mathurin, Philippe title: Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease ispublished: inpress divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G91 keywords: MASLD; MetALD; NASH; MASH; non-alcoholic fatty liver disease; alcohol-related liver disease, alcoholic liver disease, alcoholic cirrhosis; public health note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: This position statement explores the intricate relationship between alcohol intake and metabolic dysfunction in the context of the 2023 nomenclature for steatotic liver disease (SLD). Recent and lifetime alcohol use should be accurately assessed in all patients with SLD to facilitate classification of alcohol use in grams of alcohol per week. Alcohol biomarkers (i.e., phosphatidylethanol), use of validated questionnaires (i.e. AUDIT-C), and collateral information from friends and relatives could help facilitate differentiation between alcohol-related liver disease (ALD) per se and liver disease with both metabolic and alcohol-related components (MetALD). Heavy alcohol use can contribute to cardiometabolic risk factors such as high blood pressure, hypertriglyceridemia, and hyperglycemia. As a result, caution should be exercised in the application of only one metabolic dysfunction criterion to diagnose MASLD, as suggested in the 2023 nomenclature document, particularly in individuals exceeding weekly alcohol use thresholds of 140 grams for women and 210 grams for men. This is particularly important in those individuals with isolated high blood pressure, hypertriglyceridemia, or hyperglycemia, where the disease process may be driven by alcohol itself. Additionally, metabolic dysfunction and alcohol use should be reassessed over time, especially after periods of changes in risk factor exposure. This approach could ensure a more accurate prognosis and effective management of SLD addressing both metabolic and alcohol-related factors. date: 2024-11-27 date_type: published publisher: Elsevier official_url: https://doi.org/10.1016/j.jhep.2024.11.028 full_text_type: other language: eng verified: verified_manual elements_id: 2341530 doi: 10.1016/j.jhep.2024.11.028 medium: Print-Electronic pii: S0168-8278(24)02728-4 lyricists_name: Morgan, Marsha lyricists_id: MYMOR45 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: restricted publication: Journal of Hepatology event_location: Netherlands issn: 0168-8278 citation: Arab, Juan Pablo; Díaz, Luis Antonio; Rehm, Jürgen; Im, Gene; Arrese, Marco; Kamath, Patrick S; Lucey, Michael R; ... Mathurin, Philippe; + view all <#> Arab, Juan Pablo; Díaz, Luis Antonio; Rehm, Jürgen; Im, Gene; Arrese, Marco; Kamath, Patrick S; Lucey, Michael R; Mellinger, Jessica; Thiele, Maja; Thursz, Mark; Bataller, Ramon; Burton, Robyn; Chokshi, Shilpa; Francque, Sven M; Krag, Aleksander; Lackner, Carolin; Lee, Brian P; Liangpunsakul, Suthat; MacClain, Craig; Mandrekar, Pranoti; Mitchell, Mack C; Morgan, Marsha Y; Morgan, Timothy R; Pose, Elisa; Shah, Vijay H; Shawcross, Debbie; Sheron, Nick; Singal, Ashwani K; Stefanescu, Horia; Terrault, Norah; Trépo, Eric; Moreno, Christophe; Louvet, Alexandre; Mathurin, Philippe; - view fewer <#> (2024) Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease. Journal of Hepatology 10.1016/j.jhep.2024.11.028 <https://doi.org/10.1016/j.jhep.2024.11.028>. (In press). document_url: https://discovery.ucl.ac.uk/id/eprint/10201497/1/1-s2.0-S0168827824027284-main.pdf