eprintid: 10201497
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/20/14/97
datestamp: 2024-12-12 11:37:34
lastmod: 2024-12-12 11:37:34
status_changed: 2024-12-12 11:37:34
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Arab, Juan Pablo
creators_name: Díaz, Luis Antonio
creators_name: Rehm, Jürgen
creators_name: Im, Gene
creators_name: Arrese, Marco
creators_name: Kamath, Patrick S
creators_name: Lucey, Michael R
creators_name: Mellinger, Jessica
creators_name: Thiele, Maja
creators_name: Thursz, Mark
creators_name: Bataller, Ramon
creators_name: Burton, Robyn
creators_name: Chokshi, Shilpa
creators_name: Francque, Sven M
creators_name: Krag, Aleksander
creators_name: Lackner, Carolin
creators_name: Lee, Brian P
creators_name: Liangpunsakul, Suthat
creators_name: MacClain, Craig
creators_name: Mandrekar, Pranoti
creators_name: Mitchell, Mack C
creators_name: Morgan, Marsha Y
creators_name: Morgan, Timothy R
creators_name: Pose, Elisa
creators_name: Shah, Vijay H
creators_name: Shawcross, Debbie
creators_name: Sheron, Nick
creators_name: Singal, Ashwani K
creators_name: Stefanescu, Horia
creators_name: Terrault, Norah
creators_name: Trépo, Eric
creators_name: Moreno, Christophe
creators_name: Louvet, Alexandre
creators_name: Mathurin, Philippe
title: Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G91
keywords: MASLD; MetALD; NASH; MASH; non-alcoholic fatty liver disease; alcohol-related liver disease,
alcoholic liver disease, alcoholic cirrhosis; public health
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: This position statement explores the intricate relationship between alcohol intake and metabolic dysfunction in the context of the 2023 nomenclature for steatotic liver disease (SLD). Recent and lifetime alcohol use should be accurately assessed in all patients with SLD to facilitate classification of alcohol use in grams of alcohol per week. Alcohol biomarkers (i.e., phosphatidylethanol), use of validated questionnaires (i.e. AUDIT-C), and collateral information from friends and relatives could help facilitate differentiation between alcohol-related liver disease (ALD) per se and liver disease with both metabolic and alcohol-related components (MetALD). Heavy alcohol use can contribute to cardiometabolic risk factors such as high blood pressure, hypertriglyceridemia, and hyperglycemia. As a result, caution should be exercised in the application of only one metabolic dysfunction criterion to diagnose MASLD, as suggested in the 2023 nomenclature document, particularly in individuals exceeding weekly alcohol use thresholds of 140 grams for women and 210 grams for men. This is particularly important in those individuals with isolated high blood pressure, hypertriglyceridemia, or hyperglycemia, where the disease process may be driven by alcohol itself. Additionally, metabolic dysfunction and alcohol use should be reassessed over time, especially after periods of changes in risk factor exposure. This approach could ensure a more accurate prognosis and effective management of SLD addressing both metabolic and alcohol-related factors.
date: 2024-11-27
date_type: published
publisher: Elsevier
official_url: https://doi.org/10.1016/j.jhep.2024.11.028
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2341530
doi: 10.1016/j.jhep.2024.11.028
medium: Print-Electronic
pii: S0168-8278(24)02728-4
lyricists_name: Morgan, Marsha
lyricists_id: MYMOR45
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: restricted
publication: Journal of Hepatology
event_location: Netherlands
issn: 0168-8278
citation:        Arab, Juan Pablo;    Díaz, Luis Antonio;    Rehm, Jürgen;    Im, Gene;    Arrese, Marco;    Kamath, Patrick S;    Lucey, Michael R;                                                                                                             ... Mathurin, Philippe; + view all <#>        Arab, Juan Pablo;  Díaz, Luis Antonio;  Rehm, Jürgen;  Im, Gene;  Arrese, Marco;  Kamath, Patrick S;  Lucey, Michael R;  Mellinger, Jessica;  Thiele, Maja;  Thursz, Mark;  Bataller, Ramon;  Burton, Robyn;  Chokshi, Shilpa;  Francque, Sven M;  Krag, Aleksander;  Lackner, Carolin;  Lee, Brian P;  Liangpunsakul, Suthat;  MacClain, Craig;  Mandrekar, Pranoti;  Mitchell, Mack C;  Morgan, Marsha Y;  Morgan, Timothy R;  Pose, Elisa;  Shah, Vijay H;  Shawcross, Debbie;  Sheron, Nick;  Singal, Ashwani K;  Stefanescu, Horia;  Terrault, Norah;  Trépo, Eric;  Moreno, Christophe;  Louvet, Alexandre;  Mathurin, Philippe;   - view fewer <#>    (2024)    Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease.                   Journal of Hepatology        10.1016/j.jhep.2024.11.028 <https://doi.org/10.1016/j.jhep.2024.11.028>.    (In press).   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10201497/1/1-s2.0-S0168827824027284-main.pdf