<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10201037> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/title> "Nanomechanical detection to empower robust monitoring of sepsis and microbial adaptive immune system-mediated proinflammatory disease"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/abstract> "The correlation between circulating microbes and sepsis as well as proinflammatory diseases is increasingly gaining recognition. However, the detection of microbes’ cell-free DNA (cfDNA), which exist at concentrations of a billion times lower than blood proteins, poses a significant challenge for early disease detection. Here, we present Nano mechanics combined with highly sensitive readout sequences to address the challenges of ultralow counts of disease biomarkers, thus enabling robust quantitative monitoring of chronic medical conditions at different stages of human disease progression. To showcase the effectiveness of our approach, we employ fragments of cfDNA and human cell secretory proteins as models with predictive capabilities for human diseases. Notably, our method reveals a reliable representation over an impressive three to four orders of magnitude in the detection limit and dynamic range, surpassing commercially available quantitative polymerase chain reaction (qPCR) commonly used in routine clinical practice. This concept underpins a highly sensitive and selective medical device designed for the early detection of circulating microbes in patients undergoing intensive cancer therapy. This will help pinpoint individuals at risk of complications, including damage to the intestinal barrier and development of neutropenic fever/Sirsa/Sepsis. Moreover, this approach introduces new avenues for stratifying antibiotic prophylaxis in proinflammatory diseases."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/date> "2024-12-02" .
<https://discovery.ucl.ac.uk/id/document/1804929> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/volume> "14" .
<https://discovery.ucl.ac.uk/id/org/ext-dcea299cf48188065b5f59a4cae50003> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-dcea299cf48188065b5f59a4cae50003> <http://xmlns.com/foaf/0.1/name> "Springer Science and Business Media LLC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-dcea299cf48188065b5f59a4cae50003> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://xmlns.com/foaf/0.1/name> "Scientific Reports"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:20452322> .
<https://discovery.ucl.ac.uk/id/publication/ext-20452322> <http://purl.org/ontology/bibo/issn> "20452322" .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0ab5157b89a87eb87a2466ebf73363e2> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-0ab5157b89a87eb87a2466ebf73363e2> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1eaf7f48d79db951166ae1fe97abf1aa> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-1eaf7f48d79db951166ae1fe97abf1aa> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f23fbc457843a68db6bedbcf2414dc3d> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-f23fbc457843a68db6bedbcf2414dc3d> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8375f24e7df0fb6cda701eb4bac72303> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-8375f24e7df0fb6cda701eb4bac72303> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-65945a927669389b33cae770b9b2a49a> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-65945a927669389b33cae770b9b2a49a> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6e742c2c483ade78c85a4ff2ae7b393e> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-6e742c2c483ade78c85a4ff2ae7b393e> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fd42e37f91cf597625379786d18f02f4> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-fd42e37f91cf597625379786d18f02f4> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c99264c8daf14b32266cddfad5762116> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-c99264c8daf14b32266cddfad5762116> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3f8091a9a2a36351282952dd1c4d14b5> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-3f8091a9a2a36351282952dd1c4d14b5> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a534eff96cf94366c519c84d7462338a> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-a534eff96cf94366c519c84d7462338a> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8ddba05b565ecadb99f1bc08f701fe96> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-8ddba05b565ecadb99f1bc08f701fe96> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8f8b88760059fc361aa57662360e5de3> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-8f8b88760059fc361aa57662360e5de3> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a8c902cc5f12bcb532721ca44e40e8f1> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-a8c902cc5f12bcb532721ca44e40e8f1> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2b14d12ce6163098afc6108d1f002f69> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-2b14d12ce6163098afc6108d1f002f69> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a6d006ef1264aad03eb64277606608ee> .
<https://discovery.ucl.ac.uk/id/eprint/10201037> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10201037#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10201037#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-a6d006ef1264aad03eb64277606608ee> .
<https://discovery.ucl.ac.uk/id/person/ext-3f8091a9a2a36351282952dd1c4d14b5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3f8091a9a2a36351282952dd1c4d14b5> <http://xmlns.com/foaf/0.1/givenName> "Hinnerk"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3f8091a9a2a36351282952dd1c4d14b5> <http://xmlns.com/foaf/0.1/familyName> "Wulf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3f8091a9a2a36351282952dd1c4d14b5> <http://xmlns.com/foaf/0.1/name> "Hinnerk Wulf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0ab5157b89a87eb87a2466ebf73363e2> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0ab5157b89a87eb87a2466ebf73363e2> <http://xmlns.com/foaf/0.1/givenName> "Kessarin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0ab5157b89a87eb87a2466ebf73363e2> <http://xmlns.com/foaf/0.1/familyName> "Thanapirom"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0ab5157b89a87eb87a2466ebf73363e2> <http://xmlns.com/foaf/0.1/name> "Kessarin Thanapirom"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8f8b88760059fc361aa57662360e5de3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8f8b88760059fc361aa57662360e5de3> <http://xmlns.com/foaf/0.1/givenName> "Krista"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8f8b88760059fc361aa57662360e5de3> <http://xmlns.com/foaf/0.1/familyName> "Rombouts"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8f8b88760059fc361aa57662360e5de3> <http://xmlns.com/foaf/0.1/name> "Krista Rombouts"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fd42e37f91cf597625379786d18f02f4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fd42e37f91cf597625379786d18f02f4> <http://xmlns.com/foaf/0.1/givenName> "Wieland"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fd42e37f91cf597625379786d18f02f4> <http://xmlns.com/foaf/0.1/familyName> "Vogt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fd42e37f91cf597625379786d18f02f4> <http://xmlns.com/foaf/0.1/name> "Wieland Vogt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ddba05b565ecadb99f1bc08f701fe96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8ddba05b565ecadb99f1bc08f701fe96> <http://xmlns.com/foaf/0.1/givenName> "Timothy D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ddba05b565ecadb99f1bc08f701fe96> <http://xmlns.com/foaf/0.1/familyName> "McHugh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8ddba05b565ecadb99f1bc08f701fe96> <http://xmlns.com/foaf/0.1/name> "Timothy D McHugh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b14d12ce6163098afc6108d1f002f69> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2b14d12ce6163098afc6108d1f002f69> <http://xmlns.com/foaf/0.1/givenName> "Emmanouil"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b14d12ce6163098afc6108d1f002f69> <http://xmlns.com/foaf/0.1/familyName> "Tsochatzis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2b14d12ce6163098afc6108d1f002f69> <http://xmlns.com/foaf/0.1/name> "Emmanouil Tsochatzis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1eaf7f48d79db951166ae1fe97abf1aa> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1eaf7f48d79db951166ae1fe97abf1aa> <http://xmlns.com/foaf/0.1/givenName> "Walid"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1eaf7f48d79db951166ae1fe97abf1aa> <http://xmlns.com/foaf/0.1/familyName> "Al-Akkad"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1eaf7f48d79db951166ae1fe97abf1aa> <http://xmlns.com/foaf/0.1/name> "Walid Al-Akkad"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e742c2c483ade78c85a4ff2ae7b393e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6e742c2c483ade78c85a4ff2ae7b393e> <http://xmlns.com/foaf/0.1/givenName> "Stefan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e742c2c483ade78c85a4ff2ae7b393e> <http://xmlns.com/foaf/0.1/familyName> "Nardi-Hiebl"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e742c2c483ade78c85a4ff2ae7b393e> <http://xmlns.com/foaf/0.1/name> "Stefan Nardi-Hiebl"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a6d006ef1264aad03eb64277606608ee> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a6d006ef1264aad03eb64277606608ee> <http://xmlns.com/foaf/0.1/givenName> "Joseph W"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a6d006ef1264aad03eb64277606608ee> <http://xmlns.com/foaf/0.1/familyName> "Ndieyira"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a6d006ef1264aad03eb64277606608ee> <http://xmlns.com/foaf/0.1/name> "Joseph W Ndieyira"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c99264c8daf14b32266cddfad5762116> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c99264c8daf14b32266cddfad5762116> <http://xmlns.com/foaf/0.1/givenName> "Benjamin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c99264c8daf14b32266cddfad5762116> <http://xmlns.com/foaf/0.1/familyName> "Vojnar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c99264c8daf14b32266cddfad5762116> <http://xmlns.com/foaf/0.1/name> "Benjamin Vojnar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8375f24e7df0fb6cda701eb4bac72303> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
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