eprintid: 10200954
rev_number: 12
eprint_status: archive
userid: 699
dir: disk0/10/20/09/54
datestamp: 2024-12-03 08:34:41
lastmod: 2024-12-03 08:34:41
status_changed: 2024-12-03 08:34:41
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Ghani, Lubna
creators_name: Calabrese, Len
creators_name: Mehta, Puja
title: Iatrogenic HLH
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Hemophagocytic lymphohistiocytosis (HLH) can be categorized as either primary (familial, generally occurring in infants) or secondary (sHLH, occurring at any age in association with a variety of conditions) and is mainly triggered by infections, autoimmune diseases, and malignant conditions. Our understanding of the pathophysiology of sHLH is still evolving, and among the causes and associations with the syndrome, those putatively associated with iatrogenic causes remain among the most poorly understood due to the rarity of these entities and the multiple confounders so often present in the patients in whom they are reported. Herein, we present a review of the literature to describe the diagnostic and therapeutic challenges of sHLH associated with iatrogenic causes and discuss some of the challenges and future directions in our efforts to better understand these complex conditions for the advancement of patient outcomes.
date: 2024-08-09
date_type: published
publisher: Springer International Publishing
official_url: http://dx.doi.org/10.1007/978-3-031-59815-9_32
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2304175
doi: 10.1007/978-3-031-59815-9_32
medium: Print
lyricists_name: Mehta, Puja
lyricists_id: PMEHT16
actors_name: Mehta, Puja
actors_id: PMEHT16
actors_role: owner
full_text_status: restricted
publication: Cytokine Storm Syndrome: Advances in Experimental Medicine and Biology
volume: 1448
pagerange: 469-477
event_location: United States
issn: 0065-2598
citation:        Ghani, Lubna;    Calabrese, Len;    Mehta, Puja;      (2024)    Iatrogenic HLH.                   Cytokine Storm Syndrome: Advances in Experimental Medicine and Biology , 1448    pp. 469-477.    10.1007/978-3-031-59815-9_32 <https://doi.org/10.1007/978-3-031-59815-9_32>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10200954/1/Mehta_Iatrogenic%20HLH%20Ghani%20Calabrese%20Mehta.pdf