TY  - JOUR
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
EP  - 477
AV  - restricted
VL  - 1448
SP  - 469
Y1  - 2024/08/09/
TI  - Iatrogenic HLH
A1  - Ghani, Lubna
A1  - Calabrese, Len
A1  - Mehta, Puja
JF  - Cytokine Storm Syndrome: Advances in Experimental Medicine and Biology
SN  - 0065-2598
UR  - http://dx.doi.org/10.1007/978-3-031-59815-9_32
PB  - Springer International Publishing
ID  - discovery10200954
N2  - Hemophagocytic lymphohistiocytosis (HLH) can be categorized as either primary (familial, generally occurring in infants) or secondary (sHLH, occurring at any age in association with a variety of conditions) and is mainly triggered by infections, autoimmune diseases, and malignant conditions. Our understanding of the pathophysiology of sHLH is still evolving, and among the causes and associations with the syndrome, those putatively associated with iatrogenic causes remain among the most poorly understood due to the rarity of these entities and the multiple confounders so often present in the patients in whom they are reported. Herein, we present a review of the literature to describe the diagnostic and therapeutic challenges of sHLH associated with iatrogenic causes and discuss some of the challenges and future directions in our efforts to better understand these complex conditions for the advancement of patient outcomes.
ER  -