@article{discovery10200946,
          editor = {Mikael Simons},
            note = {Copyright: {\copyright} 2024 Rajani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.},
          volume = {22},
         journal = {PLoS Biology},
           title = {Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease},
            year = {2024},
       publisher = {PUBLIC LIBRARY SCIENCE},
          number = {7},
           month = {July},
        abstract = {Reduction of amyloid beta (A{\ensuremath{\beta}}) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are the main source of pathogenic A{\ensuremath{\beta}} is untested. Here, we challenge this prevailing belief by demonstrating that oligodendrocytes are an important source of A{\ensuremath{\beta}} in the human brain and play a key role in promoting abnormal neuronal hyperactivity in an AD knock-in mouse model. We show that selectively suppressing oligodendrocyte A{\ensuremath{\beta}} production improves AD brain pathology and restores neuronal function in the mouse model in vivo. Our findings suggest that targeting oligodendrocyte A{\ensuremath{\beta}} production could be a promising therapeutic strategy for treating AD.},
            issn = {1544-9173},
          author = {Rajani, Rikesh M and Ellingford, Robert and Hellmuth, Mariam and Harris, Samuel S and Taso, Orjona S and Graykowski, David and Lam, Francesca Kar Wey and Arber, Charles and Fertan, Emre and Danial, John SH and Swire, Matthew and Lloyd, Marcus and Giovannucci, Tatiana A and Bourdenx, Mathieu and Klenerman, David and Vassar, Robert and Wray, Selina and Sala Frigerio, Carlo and Busche, Marc Aurel},
             url = {http://dx.doi.org/10.1371/journal.pbio.3002727},
        keywords = {Science \& Technology, Life Sciences \& Biomedicine, Biochemistry \& Molecular Biology, Biology, Life Sciences \& Biomedicine - Other Topics, PLURIPOTENT STEM-CELLS, MOUSE MODEL, CORTEX, TRANSCRIPTOMICS, MYELINATION, INHIBITION, ASTROCYTES, PATHOLOGY, PLAQUES}
}