<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10200748> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/title> "Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/ontology/bibo/abstract> "Introduction:\r\nThe understanding of biological pathways related to loneliness and social isolation remains incomplete. Cutting-edge population-based proteomics offers opportunities to uncover novel biological pathways linked to social deficits.\r\n//\r\nMethods:\r\nThis study employed a proteome-wide and data-driven approach to estimate the cross-sectional associations between objective measures of social connections (i.e., social isolation) and subjective measures (i.e., loneliness) with protein abundance, using the English Longitudinal Study of Ageing.\r\n//\r\nResults:\r\nGreater social isolation was associated with higher levels of 11 proteins (TNFRSF10A, MMP12, TRAIL-R2, SKR3, TNFRSF11A, VSIG2, PRSS8, FGFR2, KIM1, REN, and NEFL) after minimal adjustments; and three proteins were significantly associated after full adjustments (TNFRSF10A, TNFRSF11A, and HAOX1). Findings from two-sample Mendelian randomization indicated that a lower frequency of in-person social contact with friends or family causally increased levels of TNFRSF10A, TRAIL-R2, TNFRSF11A, and KIM1, and decreased the level of NEFL. The study also highlighted several enriched biological pathways, including necrosis and cell death regulation, dimerization of procaspase-8, and inhibition of caspase-8 pathways, which have previously not been linked to social deficits.\r\n//\r\nConclusion:\r\nThese findings could help explain the relationship between social deficits and disease, confirming the importance of continuing to explore novel biological pathways associated with social deficits."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/date> "2025-02" .
<https://discovery.ucl.ac.uk/id/document/1803018> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/ontology/bibo/volume> "124" .
<https://discovery.ucl.ac.uk/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1> <http://xmlns.com/foaf/0.1/name> "Elsevier BV"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1> .
<https://discovery.ucl.ac.uk/id/publication/ext-08891591> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-08891591> <http://xmlns.com/foaf/0.1/name> "Brain, Behavior, and Immunity"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-08891591> .
<https://discovery.ucl.ac.uk/id/publication/ext-08891591> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:08891591> .
<https://discovery.ucl.ac.uk/id/publication/ext-08891591> <http://purl.org/ontology/bibo/issn> "08891591" .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-16c1cbb5ad7837ca4a77b2669417ae1c> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10200748#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10200748#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-16c1cbb5ad7837ca4a77b2669417ae1c> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-28b945145f778797d35612e94ffe8396> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10200748#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10200748#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-28b945145f778797d35612e94ffe8396> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4527db5b99a79aad3fc05cf03f1b23bd> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10200748#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10200748#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-4527db5b99a79aad3fc05cf03f1b23bd> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5a371303bd7a998a2e16c41601f1a1e9> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10200748#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10200748#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-5a371303bd7a998a2e16c41601f1a1e9> .
<https://discovery.ucl.ac.uk/id/person/ext-28b945145f778797d35612e94ffe8396> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-28b945145f778797d35612e94ffe8396> <http://xmlns.com/foaf/0.1/givenName> "Zohar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28b945145f778797d35612e94ffe8396> <http://xmlns.com/foaf/0.1/familyName> "Preminger"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-28b945145f778797d35612e94ffe8396> <http://xmlns.com/foaf/0.1/name> "Zohar Preminger"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5a371303bd7a998a2e16c41601f1a1e9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5a371303bd7a998a2e16c41601f1a1e9> <http://xmlns.com/foaf/0.1/givenName> "Daisy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5a371303bd7a998a2e16c41601f1a1e9> <http://xmlns.com/foaf/0.1/familyName> "Fancourt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5a371303bd7a998a2e16c41601f1a1e9> <http://xmlns.com/foaf/0.1/name> "Daisy Fancourt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4527db5b99a79aad3fc05cf03f1b23bd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4527db5b99a79aad3fc05cf03f1b23bd> <http://xmlns.com/foaf/0.1/givenName> "Andrew"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4527db5b99a79aad3fc05cf03f1b23bd> <http://xmlns.com/foaf/0.1/familyName> "Steptoe"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4527db5b99a79aad3fc05cf03f1b23bd> <http://xmlns.com/foaf/0.1/name> "Andrew Steptoe"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-16c1cbb5ad7837ca4a77b2669417ae1c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-16c1cbb5ad7837ca4a77b2669417ae1c> <http://xmlns.com/foaf/0.1/givenName> "Jessica"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-16c1cbb5ad7837ca4a77b2669417ae1c> <http://xmlns.com/foaf/0.1/familyName> "Gong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-16c1cbb5ad7837ca4a77b2669417ae1c> <http://xmlns.com/foaf/0.1/name> "Jessica Gong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803018> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1803018> <http://www.w3.org/2000/01/rdf-schema#label> "Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1803018> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10200748/1/Gong_1-s2.0-S0889159124007062-main.pdf> .
<https://discovery.ucl.ac.uk/id/document/1803018> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10200748/1/Gong_1-s2.0-S0889159124007062-main.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/10200748/1/Gong_1-s2.0-S0889159124007062-main.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "Gong_1-s2.0-S0889159124007062-main.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1803020> .
<https://discovery.ucl.ac.uk/id/document/1803020> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1803020> <http://www.w3.org/2000/01/rdf-schema#label> "Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1803020> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803020> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803020> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803020> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10200748/2/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/document/1803020> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10200748/2/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10200748/2/lightbox.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "lightbox.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1803021> .
<https://discovery.ucl.ac.uk/id/document/1803021> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1803021> <http://www.w3.org/2000/01/rdf-schema#label> "Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1803021> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803021> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803021> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803021> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10200748/3/preview.jpg> .
<https://discovery.ucl.ac.uk/id/document/1803021> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10200748/3/preview.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10200748/3/preview.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "preview.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1803022> .
<https://discovery.ucl.ac.uk/id/document/1803022> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1803022> <http://www.w3.org/2000/01/rdf-schema#label> "Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1803022> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803022> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803022> <http://eprints.org/relation/ismediumThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803022> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10200748/4/medium.jpg> .
<https://discovery.ucl.ac.uk/id/document/1803022> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10200748/4/medium.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10200748/4/medium.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "medium.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1803023> .
<https://discovery.ucl.ac.uk/id/document/1803023> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1803023> <http://www.w3.org/2000/01/rdf-schema#label> "Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1803023> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803023> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803023> <http://eprints.org/relation/issmallThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803023> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10200748/5/small.jpg> .
<https://discovery.ucl.ac.uk/id/document/1803023> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10200748/5/small.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10200748/5/small.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "small.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1803024> .
<https://discovery.ucl.ac.uk/id/document/1803024> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1803024> <http://www.w3.org/2000/01/rdf-schema#label> "Protein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1803024> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803024> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803024> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/1803018> .
<https://discovery.ucl.ac.uk/id/document/1803024> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10200748/6/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/document/1803024> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10200748/6/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/eprint/10200748/6/indexcodes.txt> <http://www.w3.org/2000/01/rdf-schema#label> "indexcodes.txt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200748> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://discovery.ucl.ac.uk/id/eprint/10200748/> .
<https://discovery.ucl.ac.uk/id/eprint/10200748/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #10200748 \n\nProtein signatures associated with loneliness and social isolation: Plasma proteome analyses in the English Longitudinal Study of Ageing, with causal evidence from Mendelian randomization\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/10200748/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/10200748/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10200748> .