TY  - INPR
SN  - 0305-1048
Y1  - 2024/11/20/
TI  - InterPro: the protein sequence classification resource in 2025
AV  - public
N2  - InterPro (https://www.ebi.ac.uk/interpro) is a freely accessible resource for the classification of protein sequences into families. It integrates predictive models, known as signatures, from multiple member databases to classify sequences into families and predict the presence of domains and significant sites. The InterPro database provides annotations for over 200 million sequences, ensuring extensive coverage of UniProtKB, the standard repository of protein sequences, and includes mappings to several other major resources, such as Gene Ontology (GO), Protein Data Bank in Europe (PDBe) and the AlphaFold Protein Structure Database. In this publication, we report on the status of InterPro (version 101.0), detailing new developments in the database, associated web interface and software. Notable updates include the increased integration of structures predicted by AlphaFold and the enhanced description of protein families using artificial intelligence. Over the past two years, more than 5000 new InterPro entries have been created. The InterPro website now offers access to 85 000 protein families and domains from its member databases and serves as a long-term archive for retired databases. InterPro data, software and tools are freely available.
UR  - https://doi.org/10.1093/nar/gkae1082
ID  - discovery10200737
N1  - © The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
A1  - Blum, Matthias
A1  - Andreeva, Antonina
A1  - Florentino, Laise Cavalcanti
A1  - Chuguransky, Sara Rocio
A1  - Grego, Tiago
A1  - Hobbs, Emma
A1  - Pinto, Beatriz Lazaro
A1  - Orr, Ailsa
A1  - Paysan-Lafosse, Typhaine
A1  - Ponamareva, Irina
A1  - Salazar, Gustavo A
A1  - Bordin, Nicola
A1  - Bork, Peer
A1  - Bridge, Alan
A1  - Colwell, Lucy
A1  - Gough, Julian
A1  - Haft, Daniel H
A1  - Letunic, Ivica
A1  - Llinares-López, Felipe
A1  - Marchler-Bauer, Aron
A1  - Meng-Papaxanthos, Laetitia
A1  - Mi, Huaiyu
A1  - Natale, Darren A
A1  - Orengo, Christine A
A1  - Pandurangan, Arun P
A1  - Piovesan, Damiano
A1  - Rivoire, Catherine
A1  - Sigrist, Christian JA
A1  - Thanki, Narmada
A1  - Thibaud-Nissen, Françoise
A1  - Thomas, Paul D
A1  - Tosatto, Silvio CE
A1  - Wu, Cathy H
A1  - Bateman, Alex
PB  - Oxford University Press (OUP)
JF  - Nucleic Acids Research
ER  -