eprintid: 10200667
rev_number: 14
eprint_status: archive
userid: 699
dir: disk0/10/20/06/67
datestamp: 2024-12-13 08:28:11
lastmod: 2024-12-13 08:28:11
status_changed: 2024-12-13 08:28:11
type: thesis
metadata_visibility: show
sword_depositor: 699
creators_name: Bhamani, Amyn Ahmed
title: Delivery of Lung Cancer Screening
to a large, high-risk population
ispublished: unpub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
note: CC BY-NC: Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/).  Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms.  Access may initially be restricted at the author’s request.
abstract: Introduction:
Low-Dose Computed Tomography (LDCT) screening reduces lung cancer related mortality, but screening protocols require further optimisation. In this thesis, I focused on the management of screen-detected findings and operational aspects of Lung Cancer Screening (LCS).

Methods:
First, I assessed baseline SUMMIT Study screening results to demonstrate that large-scale LCS can be delivered safely and efficiently. Next, I analysed outcomes of participants with incidental, screen-detected anterior mediastinal masses (AMM) and bronchiectasis to determine how management protocols for these findings can be optimised. I then analysed participant-reported outcomes of communicating screening results by letter to assess the feasibility of this approach in the wider context of LCS and finally, evaluated outcomes of a practitioner-made ‘opt-out’ smoking cessation referral policy for individuals currently smoking tobacco who attended a Lung Health Check (LHC) appointment. 

Results:
2.0% of SUMMIT participants were diagnosed with screen-detected lung cancer. 79% were diagnosed at an early-stage and 90% received treatment with curative intent. Most screen-detected AMM followed-up within the study remained stable on interval imaging, while adverse outcomes of clinical significance (increased burden of exacerbations and greater risk of emergency respiratory hospitalisation during follow-up) were observed amongst participants with moderate-severe, but not mild, bronchiectasis. Most participants who received their non-urgent screening results by letter reported satisfaction with this method of communication. Finally, 33% of individuals currently smoking tobacco who attended a LHC consented to a practitioner-made smoking cessation referral and the four-week quit rate amongst individuals accepting support was 18%. 

Conclusions:
Results reported in this thesis will help inform policies for the safe and efficient delivery of a national LCS programme.
date: 2024-11-28
date_type: published
full_text_type: other
thesis_class: doctoral_embargoed
thesis_award: Ph.D
language: eng
verified: verified_manual
elements_id: 2338622
lyricists_name: Bhamani, Amyn Ahmed
lyricists_id: AABHA42
actors_name: Bhamani, Amyn Ahmed
actors_id: AABHA42
actors_role: owner
full_text_status: restricted
pagerange: 1-323
pages: 323
institution: UCL (University College London)
department: Respiratory Medicine
thesis_type: Doctoral
citation:        Bhamani, Amyn Ahmed;      (2024)    Delivery of Lung Cancer Screening to a large, high-risk population.                   Doctoral thesis  (Ph.D), UCL (University College London).    
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10200667/9/Bhamani_10200667_Thesis_sigs_removed.pdf