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<https://discovery.ucl.ac.uk/id/eprint/10200667> <http://purl.org/dc/terms/title> "Delivery of Lung Cancer Screening\r\nto a large, high-risk population"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200667> <http://purl.org/ontology/bibo/abstract> "Introduction:\r\nLow-Dose Computed Tomography (LDCT) screening reduces lung cancer related mortality, but screening protocols require further optimisation. In this thesis, I focused on the management of screen-detected findings and operational aspects of Lung Cancer Screening (LCS).\r\n\r\nMethods:\r\nFirst, I assessed baseline SUMMIT Study screening results to demonstrate that large-scale LCS can be delivered safely and efficiently. Next, I analysed outcomes of participants with incidental, screen-detected anterior mediastinal masses (AMM) and bronchiectasis to determine how management protocols for these findings can be optimised. I then analysed participant-reported outcomes of communicating screening results by letter to assess the feasibility of this approach in the wider context of LCS and finally, evaluated outcomes of a practitioner-made ‘opt-out’ smoking cessation referral policy for individuals currently smoking tobacco who attended a Lung Health Check (LHC) appointment. \r\n\r\nResults:\r\n2.0% of SUMMIT participants were diagnosed with screen-detected lung cancer. 79% were diagnosed at an early-stage and 90% received treatment with curative intent. Most screen-detected AMM followed-up within the study remained stable on interval imaging, while adverse outcomes of clinical significance (increased burden of exacerbations and greater risk of emergency respiratory hospitalisation during follow-up) were observed amongst participants with moderate-severe, but not mild, bronchiectasis. Most participants who received their non-urgent screening results by letter reported satisfaction with this method of communication. Finally, 33% of individuals currently smoking tobacco who attended a LHC consented to a practitioner-made smoking cessation referral and the four-week quit rate amongst individuals accepting support was 18%. \r\n\r\nConclusions:\r\nResults reported in this thesis will help inform policies for the safe and efficient delivery of a national LCS programme."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10200667> <http://purl.org/dc/terms/date> "2024-11-28" .
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