eprintid: 10200125
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/20/01/25
datestamp: 2024-11-15 10:02:09
lastmod: 2024-11-15 10:02:09
status_changed: 2024-11-15 10:02:09
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Simegn, Gizeaddis Lamesgin
creators_name: Sun, Phillip Zhe
creators_name: Zhou, Jinyuan
creators_name: Kim, Mina
creators_name: Reddy, Ravinder
creators_name: Zu, Zhongliang
creators_name: Zaiss, Moritz
creators_name: Yadav, Nirbhay Narayan
creators_name: Edden, Richard AE
creators_name: van Zijl, Peter CM
creators_name: Knutsson, Linda
title: Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review
ispublished: inpress
divisions: UCL
divisions: B04
divisions: F42
keywords: APT MRI, B0 inhomogeneity, B1+ inhomogeneity, CEST MRI, motion correction, prospective correction, retrospective correction, shim correction
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a powerful imaging technique sensitive to tissue molecular composition, pH, and metabolic processes in situ. CEST MRI uniquely probes the physical exchange of protons between water and specific molecules within tissues, providing a window into physiological phenomena that remain invisible to standard MRI. However, given the very low concentration (millimolar range) of CEST compounds, the effects measured are generally only on the order of a few percent of the water signal. Consequently, a few critical challenges, including correction of motion artifacts and magnetic field (B0 and B1+) inhomogeneities, have to be addressed in order to unlock the full potential of CEST MRI. Motion, whether from patient movement or inherent physiological pulsations, can distort the CEST signal, hindering accurate quantification. B0 and B1+ inhomogeneities, arising from scanner hardware imperfections, further complicate data interpretation by introducing spurious variations in the signal intensity. Without proper correction of these confounding factors, reliable analysis and clinical translation of CEST MRI remain challenging. Motion correction methods aim to compensate for patient movement during (prospective) or after (retrospective) image acquisition, reducing artifacts and preserving data quality. Similarly, B0 and B1+ inhomogeneity correction techniques enhance the spatial and spectral accuracy of CEST MRI. This paper aims to provide a comprehensive review of the current landscape of motion and magnetic field inhomogeneity correction methods in CEST MRI. The methods discussed apply to saturation transfer (ST) MRI in general, including semisolid magnetization transfer contrast (MTC) and relayed nuclear Overhauser enhancement (rNOE) studies.
date: 2024-11-12
date_type: published
publisher: Wiley
official_url: http://dx.doi.org/10.1002/nbm.5294
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2335421
doi: 10.1002/nbm.5294
lyricists_name: Kim, Mina
lyricists_id: MKIMA96
actors_name: Kim, Mina
actors_id: MKIMA96
actors_role: owner
full_text_status: restricted
publication: NMR in Biomedicine
article_number: e5294
issn: 0952-3480
citation:        Simegn, Gizeaddis Lamesgin;    Sun, Phillip Zhe;    Zhou, Jinyuan;    Kim, Mina;    Reddy, Ravinder;    Zu, Zhongliang;    Zaiss, Moritz;                 ... Knutsson, Linda; + view all <#>        Simegn, Gizeaddis Lamesgin;  Sun, Phillip Zhe;  Zhou, Jinyuan;  Kim, Mina;  Reddy, Ravinder;  Zu, Zhongliang;  Zaiss, Moritz;  Yadav, Nirbhay Narayan;  Edden, Richard AE;  van Zijl, Peter CM;  Knutsson, Linda;   - view fewer <#>    (2024)    Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review.                   NMR in Biomedicine      , Article e5294.  10.1002/nbm.5294 <https://doi.org/10.1002/nbm.5294>.    (In press).   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10200125/1/Motion%20and%20Magnetic%20Field%20Inhomogeneity%20Correction%20Techniques%20for%20CEST_review_clean.pdf