eprintid: 10199903 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/19/99/03 datestamp: 2024-11-11 15:54:30 lastmod: 2024-11-11 15:54:30 status_changed: 2024-11-11 15:54:30 type: article metadata_visibility: show sword_depositor: 699 creators_name: Hrbacek, Jan creators_name: Kacperek, Andrzej creators_name: Beenakker, Jan-Willem M creators_name: Mortimer, Linda creators_name: Denker, Andrea creators_name: Mazal, Alejandro creators_name: Shih, Helen A creators_name: Dendale, Remi creators_name: Slopsema, Roelf creators_name: Heufelder, Jens creators_name: Mishra, Kavita K title: PTCOG Ocular Statement: Expert Summary of Current Practices and Future Developments in Ocular Proton Therapy ispublished: inpress divisions: UCL divisions: B04 divisions: F42 note: © The Author(s), 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ abstract: Although rare cancers, ocular tumors are a threat to vision, quality of life, and potentially life expectancy of a patient. Ocular proton therapy (OPT) is a powerful tool for successfully treating this disease. The Particle Therapy Co-Operative Ocular Group) formulated an Evidence and Expert-Based Executive Summary of Current Practices and Future Developments in OPT: comparative dosimetric and clinical analysis with the different OPT systems is essential to set up planning guidelines, implement best practices, and establish benchmarks for eye preservation, vision, and quality of life measures. Contemporary prospective trials in select subsets of patients (eg, tumors near the optic disc and/or macula) may allow for dosimetric and clinical analysis between different radiation modalities and beamline systems to evaluate differences in radiation delivery and penumbra, and resultant tumor control, normal tissue complication rates, and overall clinical cost-effectiveness. To date, the combination of multimodal imaging (fundus photography, ultrasound, etc), ophthalmologist assessment, and clip surgery with radiation planning have been keys to successful treatment. Increased use of three-dimensional imaging (computed tomography/magnetic resonance imaging) is anticipated although its spatial resolution might be a limiting factor (eg, detection of flat diffuse tumor parts). Commercially produced ocular treatment-planning systems are under development and their future use is expected to expand across OPT centers. Future continuity of OPT will depend on the following: (1) maintaining and upgrading existing older dedicated low-energy facilities, (2) maintaining shared, degraded beamlines at large proton therapy centers, and (3) developing adapted gantry beams of sufficient quality to maintain the clinical benefits of sharp beam conformity. Option (1) potentially offers the sharpest beams, minimizing impact on healthy tissues, whereas (2) and (3) potentially offer the advantage of substantial long-term technical support and development as well as the introduction of new approaches. Significant patient throughputs and close cooperation between medical physics, ophthalmology, and radiation therapy, underpinned by mutual understanding, is crucial for a successful OPT service. date: 2024-07-04 date_type: published publisher: Elsevier BV official_url: https://doi.org/10.1016/j.ijrobp.2024.06.017 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2305262 doi: 10.1016/j.ijrobp.2024.06.017 medium: Print-Electronic pii: S0360-3016(24)00748-X lyricists_name: Kacperek, Andrzej lyricists_id: AKACP82 actors_name: Kacperek, Andrzej actors_id: AKACP82 actors_role: owner full_text_status: public publication: International Journal of Radiation Oncology*Biology*Physics event_location: United States issn: 0360-3016 citation: Hrbacek, Jan; Kacperek, Andrzej; Beenakker, Jan-Willem M; Mortimer, Linda; Denker, Andrea; Mazal, Alejandro; Shih, Helen A; ... Mishra, Kavita K; + view all <#> Hrbacek, Jan; Kacperek, Andrzej; Beenakker, Jan-Willem M; Mortimer, Linda; Denker, Andrea; Mazal, Alejandro; Shih, Helen A; Dendale, Remi; Slopsema, Roelf; Heufelder, Jens; Mishra, Kavita K; - view fewer <#> (2024) PTCOG Ocular Statement: Expert Summary of Current Practices and Future Developments in Ocular Proton Therapy. International Journal of Radiation Oncology*Biology*Physics 10.1016/j.ijrobp.2024.06.017 <https://doi.org/10.1016/j.ijrobp.2024.06.017>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10199903/1/2024%20PTCOG%20Ocular%20Statement%20Expert%20Summary%20of%20Current%20Practices%20and%20Future%20Developments%20IJROBP.pdf