TY  - JOUR
N1  - This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
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VL  - 22
PB  - Public Library of Science (PLoS)
JF  - PLOS Biology
A1  - Romani, Armando
A1  - Antonietti, Alberto
A1  - Bella, Davide
A1  - Budd, Julian
A1  - Giacalone, Elisabetta
A1  - Kurban, Kerem
A1  - Sáray, Sára
A1  - Abdellah, Marwan
A1  - Arnaudon, Alexis
A1  - Boci, Elvis
A1  - Colangelo, Cristina
A1  - Courcol, Jean-Denis
A1  - Delemontex, Thomas
A1  - Ecker, András
A1  - Falck, Joanne
A1  - Favreau, Cyrille
A1  - Gevaert, Michael
A1  - Hernando, Juan B
A1  - Herttuainen, Joni
A1  - Ivaska, Genrich
A1  - Kanari, Lida
A1  - Kaufmann, Anna-Kristin
A1  - King, James Gonzalo
A1  - Kumbhar, Pramod
A1  - Lange, Sigrun
A1  - Lu, Huanxiang
A1  - Lupascu, Carmen Alina
A1  - Migliore, Rosanna
A1  - Petitjean, Fabien
A1  - Planas, Judit
A1  - Rai, Pranav
A1  - Ramaswamy, Srikanth
A1  - Reimann, Michael W
A1  - Riquelme, Juan Luis
A1  - Román Guerrero, Nadir
A1  - Shi, Ying
A1  - Sood, Vishal
A1  - Sy, Mohameth François
A1  - Van Geit, Werner
A1  - Vanherpe, Liesbeth
A1  - Freund, Tamás F
A1  - Mercer, Audrey
A1  - Muller, Eilif
A1  - Schürmann, Felix
A1  - Thomson, Alex M
A1  - Migliore, Michele
A1  - Káli, Szabolcs
A1  - Markram, Henry
AV  - public
TI  - Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region
Y1  - 2024/11/05/
UR  - http://dx.doi.org/10.1371/journal.pbio.3002861
ID  - discovery10199884
N2  - The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, it has been challenging to integrate information obtained from diverse experimental approaches. To address this challenge, we present a community-based, full-scale in silico model of the rat CA1 that integrates a broad range of experimental data, from synapse to network, including the reconstruction of its principal afferents, the Schaffer collaterals, and a model of the effects that acetylcholine has on the system. We tested and validated each model component and the final network model, and made input data, assumptions, and strategies explicit and transparent. The unique flexibility of the model allows scientists to potentially address a range of scientific questions. In this article, we describe the methods used to set up simulations to reproduce in vitro and in vivo experiments. Among several applications in the article, we focus on theta rhythm, a prominent hippocampal oscillation associated with various behavioral correlates and use our computer model to reproduce experimental findings. Finally, we make data, code, and model available through the hippocampushub.eu portal, which also provides an extensive set of analyses of the model and a user-friendly interface to facilitate adoption and usage. This community-based model represents a valuable tool for integrating diverse experimental data and provides a foundation for further research into the complex workings of the hippocampal CA1 region.
IS  - 11
ER  -