@article{discovery10199884,
            year = {2024},
           title = {Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region},
         journal = {PLOS Biology},
          number = {11},
            note = {This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/},
           month = {November},
          volume = {22},
       publisher = {Public Library of Science (PLoS)},
          editor = {Jozsef Csicsvari},
          author = {Romani, Armando and Antonietti, Alberto and Bella, Davide and Budd, Julian and Giacalone, Elisabetta and Kurban, Kerem and S{\'a}ray, S{\'a}ra and Abdellah, Marwan and Arnaudon, Alexis and Boci, Elvis and Colangelo, Cristina and Courcol, Jean-Denis and Delemontex, Thomas and Ecker, Andr{\'a}s and Falck, Joanne and Favreau, Cyrille and Gevaert, Michael and Hernando, Juan B and Herttuainen, Joni and Ivaska, Genrich and Kanari, Lida and Kaufmann, Anna-Kristin and King, James Gonzalo and Kumbhar, Pramod and Lange, Sigrun and Lu, Huanxiang and Lupascu, Carmen Alina and Migliore, Rosanna and Petitjean, Fabien and Planas, Judit and Rai, Pranav and Ramaswamy, Srikanth and Reimann, Michael W and Riquelme, Juan Luis and Rom{\'a}n Guerrero, Nadir and Shi, Ying and Sood, Vishal and Sy, Mohameth Fran{\cc}ois and Van Geit, Werner and Vanherpe, Liesbeth and Freund, Tam{\'a}s F and Mercer, Audrey and Muller, Eilif and Sch{\"u}rmann, Felix and Thomson, Alex M and Migliore, Michele and K{\'a}li, Szabolcs and Markram, Henry},
        abstract = {The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, it has been challenging to integrate information obtained from diverse experimental approaches. To address this challenge, we present a community-based, full-scale in silico model of the rat CA1 that integrates a broad range of experimental data, from synapse to network, including the reconstruction of its principal afferents, the Schaffer collaterals, and a model of the effects that acetylcholine has on the system. We tested and validated each model component and the final network model, and made input data, assumptions, and strategies explicit and transparent. The unique flexibility of the model allows scientists to potentially address a range of scientific questions. In this article, we describe the methods used to set up simulations to reproduce in vitro and in vivo experiments. Among several applications in the article, we focus on theta rhythm, a prominent hippocampal oscillation associated with various behavioral correlates and use our computer model to reproduce experimental findings. Finally, we make data, code, and model available through the hippocampushub.eu portal, which also provides an extensive set of analyses of the model and a user-friendly interface to facilitate adoption and usage. This community-based model represents a valuable tool for integrating diverse experimental data and provides a foundation for further research into the complex workings of the hippocampal CA1 region.},
             url = {http://dx.doi.org/10.1371/journal.pbio.3002861}
}