TY  - UNPB
PB  - UCL (University College London)
UR  - https://discovery.ucl.ac.uk/id/eprint/10198526/
ID  - discovery10198526
N2  - Low dose CT (LDCT) lung cancer screening in a high-risk population has been demonstrated in
clinical trials to reduce lung cancer mortality by 20-24%. However, the debate on whether a
screening programme for lung cancer could be cost effective is ongoing with few estimates of
the cost-benefit for a UK setting. Although, the UK Screening Committee have recommended
a lung cancer screening programme in the UK, evidence such a programme is cost effective
and the most efficient protocol for delivering such a programme is incomplete.
The SUMMIT study is a London based study which aimed to assess the feasibility of
implementing LDCT lung cancer screening for a high-risk population in a UK setting. This study
adds relevant evidence on multiple aspects of lung cancer screening which can be used to
provide UK relevant estimates on which to base a cost effectiveness analysis.
The first section of this thesis describes the analysis of SUMMIT and population data to
estimate input parameters for an economic model based on the SUMMIT population and
explores uncertainty and sub-group differences in estimates to guide sub-group and sensitivity
analysis. This section analyses costs of a screening programme, costs of diagnosis and
management of screening outcomes, life expectancy and quality of life and probability of
specific screening outcomes to inform transition probabilities within a model.
The second section of this thesis, describes the development of an economic model to
estimate the cost-effectiveness of lung cancer screening. Using the parameter estimates
derived in the first section of the thesis, the model estimates the Incremental Cost
Effectiveness Ratio (ICER) for annual LDCT screening compared to no screening at £4,541 per
QALY. The model suggests LDCT lung cancer screening is cost effective and provides a tool
through which optimal screening scenarios can be further explored.
KW  - Lung Cancer
KW  -  Economic Evaluation
KW  -  Screening
A1  - Prendecki, Kathryn Ruth
M1  - Doctoral
EP  - 308
AV  - restricted
SP  - 24
Y1  - 2024/10/28/
TI  - Health Economic Analysis of Low Dose CT Lung Cancer Screening in a UK Setting
N1  - Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author?s request.
ER  -