eprintid: 10198457
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/19/84/57
datestamp: 2024-10-14 08:13:26
lastmod: 2024-10-14 08:13:26
status_changed: 2024-10-14 08:13:26
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Mcnicholas, Olivia C
creators_name: Jimenez-Jimenez, Diego
creators_name: Oliveira, Joana FA
creators_name: Ferguson, Lauren
creators_name: Bellampalli, Ravishankara
creators_name: McLaughlin, Charlotte
creators_name: Chowdhury, Fahmida Amin
creators_name: Custodio, Helena Martins
creators_name: Moloney, Patrick
creators_name: Mavrogianni, Anna
creators_name: Diehl, Beate
creators_name: Sisodiya, Sanjay M
title: The influence of temperature and genomic variation on intracranial EEG measures in people with epilepsy
ispublished: pub
divisions: UCL
divisions: B02
divisions: B04
divisions: C07
divisions: C04
divisions: D07
divisions: F81
divisions: F34
keywords: Epilepsy, EEG, seizures, climate change, heatwaves
note: Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Heatwaves have serious impacts on human health and constitute a key health concern from anthropogenic climate change. People have different individual tolerance for heatwaves or unaccustomed temperatures. Those with epilepsy may be particularly affected by temperature as the electroclinical hallmarks of brain excitability in epilepsy (inter-ictal epileptiform discharges and seizures) are influenced by a range of physiological and non-physiological conditions. Heatwaves are becoming more common and may affect brain excitability. Leveraging spontaneous heatwaves during periods of intracranial EEG recording in participants with epilepsy in a non–air-conditioned telemetry unit at the National Hospital for Neurology and Neurosurgery in London from May to August 2015–22, we examined the impact of heatwaves on brain excitability. In London, a heatwave is defined as three or more consecutive days with daily maximum temperatures ≥28°C. For each participant, we counted inter-ictal epileptiform discharges using four 10-min segments within, and outside of, heatwaves during periods of intracranial EEG recording. Additionally, we counted all clinical and subclinical seizures within, and outside of, heatwaves. We searched for causal rare genetic variants and calculated the epilepsy PRS. Nine participants were included in the study (six men, three women), median age 30 years (range 24–39). During heatwaves, there was a significant increase in the number of inter-ictal epileptiform discharges in three participants. Five participants had more seizures during the heatwave period, and as a group, there were significantly more seizures during the heatwaves. Genetic data, available for eight participants, showed none had known rare, genetically-determined epilepsies, whilst all had high polygenic risk scores for epilepsy. For some people with epilepsy, and not just those with known, rare, temperature-sensitive epilepsies, there is an association between heatwaves and increased brain excitability. These preliminary data require further validation and exploration, as they raise concerns about the impact of heatwaves directly on brain health.
date: 2024-09-10
date_type: published
publisher: OXFORD UNIV PRESS
official_url: http://dx.doi.org/10.1093/braincomms/fcae269
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2312557
doi: 10.1093/braincomms/fcae269
medium: Electronic-eCollection
pii: fcae269
lyricists_name: Martins, Helena
lyricists_name: Sisodiya, Sanjay
lyricists_name: Diehl, Beate
lyricists_name: Mavrogianni, Anna
lyricists_id: HMART83
lyricists_id: SMSIS90
lyricists_id: BDIEH56
lyricists_id: AMAVR49
actors_name: Mavrogianni, Anna
actors_id: AMAVR49
actors_role: owner
funding_acknowledgements: [Epilepsy Society]; [National Institute for Health Research]; [NHS England]; [Wellcome Trust]; [Cancer Research UK]; [Medical Research Council]
full_text_status: public
publication: Brain Communications
volume: 6
number: 5
article_number: fcae269
pages: 13
event_location: England
issn: 2632-1297
citation:        Mcnicholas, Olivia C;    Jimenez-Jimenez, Diego;    Oliveira, Joana FA;    Ferguson, Lauren;    Bellampalli, Ravishankara;    McLaughlin, Charlotte;    Chowdhury, Fahmida Amin;                     ... Sisodiya, Sanjay M; + view all <#>        Mcnicholas, Olivia C;  Jimenez-Jimenez, Diego;  Oliveira, Joana FA;  Ferguson, Lauren;  Bellampalli, Ravishankara;  McLaughlin, Charlotte;  Chowdhury, Fahmida Amin;  Custodio, Helena Martins;  Moloney, Patrick;  Mavrogianni, Anna;  Diehl, Beate;  Sisodiya, Sanjay M;   - view fewer <#>    (2024)    The influence of temperature and genomic variation on intracranial EEG measures in people with epilepsy.                   Brain Communications , 6  (5)    , Article fcae269.  10.1093/braincomms/fcae269 <https://doi.org/10.1093/braincomms%2Ffcae269>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10198457/1/fcae269.pdf