TY  - JOUR
AV  - public
TI  - Two Facets of Shear Stress Post Drug Coating Balloon: Angiography Versus Optical Coherence Tomography Fusion Approach
Y1  - 2024/04//
SN  - 1941-9651
ID  - discovery10197953
UR  - http://dx.doi.org/10.1161/circimaging.123.016279
IS  - 4
N2  - A 58-year-old patient with hypertension, dyslipidemia, and typical angina symptoms was referred for a coronary angiogram following a computed tomography coronary angiogram showing a significant stenosis in the left circumflex artery (Figure 1A). This demonstrated moderate stenosis with a minimum lumen diameter (MLD) of 1.2 mm, diameter stenosis of 51%, and a quantitative flow ratio (QFR, Medis Imaging, Leiden, the Netherlands) assessment of 0.80 indicating a flow-limiting stenosis (Figure 1B). The patient was enrolled in the randomized TRANSFORM-I trial (Treatment of Small Coronary Vessels: MagicTouch Sirolimus Coated Balloon, NCT03913832),1 comparing the novel Magic Touch sirolimus-coated balloon (Concept Medical, Surat, India) to the SeQuent Please Neo paclitaxel-coated balloon (B.Braun, Berlin, Germany) in small vessels. The patient received treatment with a 2.5×30 mm SeQuent paclitaxel-coated balloon. The balloon was inflated for 60 s, resulting in an acute gain of 0.60 mm (MLD preprocedure versus MLD postprocedure: 1.20 versus 1.80 mm) and an improved postprocedure QFR of 0.91 (Figure 1C and 1D). The patient underwent optical coherence tomography (OCT) imaging postprocedure, which showed a minimum lumen area of 2.36 mm2 and an area stenosis of 46%, respectively. In addition, OCT revealed a nonflow-limiting dissection 12.6 mm in length (Figure 1E and 1F) that extended to the media with a maximum dissection arc of 153°, and a large dissection volume of 13.8 mm3 (Video S1).
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
VL  - 17
KW  - Blood viscosity; coronary angiography; 
hemodynamic; image processing
KW  -  computer-assisted; 
tomography
KW  -  optical coherence
JF  - Circulation: Cardiovascular Imaging
PB  - American Heart Association
A1  - Poon, Eric KW
A1  - Ninomiya, Kai
A1  - Kageyama, Shigetaka
A1  - Guo, Xiaojing
A1  - Reimers, Bernhard
A1  - Torii, Ryo
A1  - Dijkstra, Jouke
A1  - Bourantas, Christos V
A1  - Reiber, Johan HC
A1  - Barlis, Peter
A1  - Onuma, Yoshinobu
A1  - Serruys, Patrick W
ER  -