%0 Journal Article
%@ 1941-9651
%A Poon, Eric KW
%A Ninomiya, Kai
%A Kageyama, Shigetaka
%A Guo, Xiaojing
%A Reimers, Bernhard
%A Torii, Ryo
%A Dijkstra, Jouke
%A Bourantas, Christos V
%A Reiber, Johan HC
%A Barlis, Peter
%A Onuma, Yoshinobu
%A Serruys, Patrick W
%D 2024
%F discovery:10197953
%I American Heart Association
%J Circulation: Cardiovascular Imaging
%K Blood viscosity; coronary angiography;   hemodynamic; image processing, computer-assisted;   tomography, optical coherence
%N 4
%T Two Facets of Shear Stress Post Drug Coating Balloon: Angiography Versus Optical Coherence Tomography Fusion Approach
%U https://discovery.ucl.ac.uk/id/eprint/10197953/
%V 17
%X A 58-year-old patient with hypertension, dyslipidemia, and typical angina symptoms was referred for a coronary angiogram following a computed tomography coronary angiogram showing a significant stenosis in the left circumflex artery (Figure 1A). This demonstrated moderate stenosis with a minimum lumen diameter (MLD) of 1.2 mm, diameter stenosis of 51%, and a quantitative flow ratio (QFR, Medis Imaging, Leiden, the Netherlands) assessment of 0.80 indicating a flow-limiting stenosis (Figure 1B). The patient was enrolled in the randomized TRANSFORM-I trial (Treatment of Small Coronary Vessels: MagicTouch Sirolimus Coated Balloon, NCT03913832),1 comparing the novel Magic Touch sirolimus-coated balloon (Concept Medical, Surat, India) to the SeQuent Please Neo paclitaxel-coated balloon (B.Braun, Berlin, Germany) in small vessels. The patient received treatment with a 2.5×30 mm SeQuent paclitaxel-coated balloon. The balloon was inflated for 60 s, resulting in an acute gain of 0.60 mm (MLD preprocedure versus MLD postprocedure: 1.20 versus 1.80 mm) and an improved postprocedure QFR of 0.91 (Figure 1C and 1D). The patient underwent optical coherence tomography (OCT) imaging postprocedure, which showed a minimum lumen area of 2.36 mm2 and an area stenosis of 46%, respectively. In addition, OCT revealed a nonflow-limiting dissection 12.6 mm in length (Figure 1E and 1F) that extended to the media with a maximum dissection arc of 153°, and a large dissection volume of 13.8 mm3 (Video S1).
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.