eprintid: 10197670 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/19/76/70 datestamp: 2024-09-27 11:51:05 lastmod: 2024-09-27 11:51:05 status_changed: 2024-09-27 11:51:05 type: article metadata_visibility: show sword_depositor: 699 creators_name: Xavier-Júnior, FH creators_name: Lopes, RMJ creators_name: Mellor, RD creators_name: Uchegbu, IF creators_name: Schätzlein, AG title: The influence of amphiphilic quaternary ammonium palmitoyl glycol chitosan (GCPQ) polymer composition on oil-loaded nanocapsule architecture ispublished: inpress divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G08 divisions: G09 keywords: Colloidal interface, GCPQ, Nanocapsules, Nanostructure, Rational design note: Crown Copyright © 2024 Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) abstract: Hypothesis: Predicting the exact nature of the self-assembly of amphiphilic molecules into supramolecular structures is of utmost importance for a variety of applications, but this is a challenge for nanotechnology. The amphiphilic drug delivery polymer-N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ) self-assembles in aqueous media to form nanoparticles. Experiment: This work aimed to develop a systematic predictive mathematical model on the eventual nature of oil-loaded GCPQ-nanoparticles and to determine the main independent variables that affect their nanoarchitecture following self-assembly. GCPQ polymers were produced with varying degree of palmitoylation (DP, 5.7–23.8 mol%), degree of quaternization (DQ, 7.2–22.7 mol%), and molecular weight (MW, 11.2–44.2 kDa) and their critical hydrophilic-lipophilic balance (cHLB) optimized to produce oil-loaded nanocapsules. Findings: Non-linear mathematical models (Particle size (nm) = 466.05 − 5.64DP − 6.52DQ + 0.13DQ2 − 0.03 MW2 − 14.48cHLB + 0.48cHLB2) were derived to predict the nanoparticle sizes (R2 = 0.998, R2adj = 0.995). Smaller nanoparticle sizes (148–157 nm) were obtained at high DP, DQ, and cHLB values, in which DP was the main independent variable responsible for nanoparticle size. Single or multiple-oil cores with small particles stabilizing polymer shells could be observed depending on the oil volume. Nanoparticle architectures, especially the nature of the oil-core(s), were driven by the DP, DQ, cHLB, and oil concentration. Here, we have developed a predictive model that may be applied to understand the nanoarchitecture of oil-loaded GCPQ-nanoparticles. date: 2025-01-15 date_type: published publisher: Elsevier BV official_url: http://dx.doi.org/10.1016/j.jcis.2024.08.250 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2319477 doi: 10.1016/j.jcis.2024.08.250 medium: Print-Electronic pii: S0021-9797(24)02039-3 lyricists_name: Uchegbu, Ijeoma lyricists_name: Schatzlein, Andreas lyricists_id: IFUCH91 lyricists_id: AGSCH58 actors_name: Harris, Jean actors_id: JAHAR68 actors_role: owner funding_acknowledgements: 88881.170785/2018-01 [CAPES] full_text_status: public publication: Journal of Colloid and Interface Science volume: 678 number: Pt B pagerange: 1181-1193 event_location: United States issn: 0021-9797 citation: Xavier-Júnior, FH; Lopes, RMJ; Mellor, RD; Uchegbu, IF; Schätzlein, AG; (2025) The influence of amphiphilic quaternary ammonium palmitoyl glycol chitosan (GCPQ) polymer composition on oil-loaded nanocapsule architecture. Journal of Colloid and Interface Science , 678 (Pt B) pp. 1181-1193. 10.1016/j.jcis.2024.08.250 <https://doi.org/10.1016/j.jcis.2024.08.250>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10197670/1/1-s2.0-S0021979724020393-main.pdf