TY  - INPR
ID  - discovery10197670
N2  - Hypothesis: Predicting the exact nature of the self-assembly of amphiphilic molecules into supramolecular structures is of utmost importance for a variety of applications, but this is a challenge for nanotechnology. The amphiphilic drug delivery polymer-N-palmitoyl-N-monomethyl-N,N-dimethyl-N,N,N-trimethyl-6-O-glycolchitosan (GCPQ) self-assembles in aqueous media to form nanoparticles. Experiment: This work aimed to develop a systematic predictive mathematical model on the eventual nature of oil-loaded GCPQ-nanoparticles and to determine the main independent variables that affect their nanoarchitecture following self-assembly. GCPQ polymers were produced with varying degree of palmitoylation (DP, 5.7?23.8 mol%), degree of quaternization (DQ, 7.2?22.7 mol%), and molecular weight (MW, 11.2?44.2 kDa) and their critical hydrophilic-lipophilic balance (cHLB) optimized to produce oil-loaded nanocapsules. Findings: Non-linear mathematical models (Particle size (nm) = 466.05 ? 5.64DP ? 6.52DQ + 0.13DQ2 ? 0.03 MW2 ? 14.48cHLB + 0.48cHLB2) were derived to predict the nanoparticle sizes (R2 = 0.998, R2adj = 0.995). Smaller nanoparticle sizes (148?157 nm) were obtained at high DP, DQ, and cHLB values, in which DP was the main independent variable responsible for nanoparticle size. Single or multiple-oil cores with small particles stabilizing polymer shells could be observed depending on the oil volume. Nanoparticle architectures, especially the nature of the oil-core(s), were driven by the DP, DQ, cHLB, and oil concentration. Here, we have developed a predictive model that may be applied to understand the nanoarchitecture of oil-loaded GCPQ-nanoparticles.
PB  - Elsevier BV
KW  - Colloidal interface
KW  -  GCPQ
KW  -  Nanocapsules
KW  -  Nanostructure
KW  -  Rational design
TI  - The influence of amphiphilic quaternary ammonium palmitoyl glycol chitosan (GCPQ) polymer composition on oil-loaded nanocapsule architecture
EP  - 1193
AV  - public
Y1  - 2025/01/15/
SN  - 0021-9797
UR  - http://dx.doi.org/10.1016/j.jcis.2024.08.250
JF  - Journal of Colloid and Interface Science
A1  - Xavier-Júnior, FH
A1  - Lopes, RMJ
A1  - Mellor, RD
A1  - Uchegbu, IF
A1  - Schätzlein, AG
SP  - 1181
VL  - 678
N1  - Crown Copyright © 2024 Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
IS  - Pt B
ER  -