<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10197584> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/title> "Learnable real-time inference of molecular composition from diffuse spectroscopy of brain tissue"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/abstract> "SIGNIFICANCE: \r\nDiffuse optical modalities such as broadband near-infrared spectroscopy (bNIRS) and hyperspectral imaging (HSI) represent a promising alternative for low-cost, non-invasive, and fast monitoring of living tissue. Particularly, the possibility of extracting the molecular composition of the tissue from the optical spectra deems the spectroscopy techniques as a unique diagnostic tool.\r\n\r\n\r\nAIMS: \r\nNo established method exists to streamline the inference of the biochemical composition from the optical spectrum for real-time applications such as surgical monitoring. We analyze a machine learning technique for inference of changes in the molecular composition of brain tissue.\r\n\r\n\r\nAPPROACH: \r\nWe propose modifications to the existing learnable methodology based on the Beer–Lambert law. We evaluate the method’s applicability to linear and nonlinear formulations of this physical law. The approach is tested on data obtained from the bNIRS- and HSI-based monitoring of brain tissue.\r\n\r\n\r\n\r\nRESULTS: \r\nThe results demonstrate that the proposed method enables real-time molecular composition inference while maintaining the accuracy of traditional methods. Preliminary findings show that Beer–Lambert law-based spectral unmixing allows contrasting brain anatomy semantics such as the vessel tree and tumor area.\r\n\r\n\r\nCONCLUSION: \r\nWe present a data-driven technique for inferring molecular composition change from diffuse spectroscopy of brain tissue, potentially enabling intra-operative monitoring."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/date> "2024-09-24" .
<https://discovery.ucl.ac.uk/id/document/1779415> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/volume> "29" .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/issue> "09" .
<https://discovery.ucl.ac.uk/id/org/ext-57a58d8a2aea7b7c8e98df9da8dc25dd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-57a58d8a2aea7b7c8e98df9da8dc25dd> <http://xmlns.com/foaf/0.1/name> "SPIE-Intl Soc Optical Eng"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-57a58d8a2aea7b7c8e98df9da8dc25dd> .
<https://discovery.ucl.ac.uk/id/publication/ext-10833668> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-10833668> <http://xmlns.com/foaf/0.1/name> "Journal of Biomedical Optics"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-10833668> .
<https://discovery.ucl.ac.uk/id/publication/ext-10833668> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:10833668> .
<https://discovery.ucl.ac.uk/id/publication/ext-10833668> <http://purl.org/ontology/bibo/issn> "10833668" .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-10d14544321bb72c74d375c2ab998ef3> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-10d14544321bb72c74d375c2ab998ef3> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1858aa7e9f3975d4fbd4a59aa28e43c1> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-1858aa7e9f3975d4fbd4a59aa28e43c1> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8574835c81c3c358b7ea1bc7231f3c9b> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-8574835c81c3c358b7ea1bc7231f3c9b> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0db96a15ce65a63cf89aeff6691ca1f5> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-0db96a15ce65a63cf89aeff6691ca1f5> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-33fbfa7b3a425a2b373d11a0b4143bef> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-33fbfa7b3a425a2b373d11a0b4143bef> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d3843371b4c94eedada80c0c900a4c74> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-d3843371b4c94eedada80c0c900a4c74> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e561ba802d45442277f4ba090fe99b05> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-e561ba802d45442277f4ba090fe99b05> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1fa2326bf9d686a939d3b99a40919f4e> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-1fa2326bf9d686a939d3b99a40919f4e> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5df4d55ccd7cc0e876f9534feda88c40> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-5df4d55ccd7cc0e876f9534feda88c40> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-30914a32460173d22241ca8751a932f5> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-30914a32460173d22241ca8751a932f5> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-206599148012342784b9a9644ffda72c> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-206599148012342784b9a9644ffda72c> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1e9c33d3c96bf9e69fd597f57e4cba73> .
<https://discovery.ucl.ac.uk/id/eprint/10197584> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10197584#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10197584#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-1e9c33d3c96bf9e69fd597f57e4cba73> .
<https://discovery.ucl.ac.uk/id/person/ext-1fa2326bf9d686a939d3b99a40919f4e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1fa2326bf9d686a939d3b99a40919f4e> <http://xmlns.com/foaf/0.1/givenName> "Charly"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1fa2326bf9d686a939d3b99a40919f4e> <http://xmlns.com/foaf/0.1/familyName> "Caredda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1fa2326bf9d686a939d3b99a40919f4e> <http://xmlns.com/foaf/0.1/name> "Charly Caredda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-206599148012342784b9a9644ffda72c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-206599148012342784b9a9644ffda72c> <http://xmlns.com/foaf/0.1/givenName> "Ilias"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-206599148012342784b9a9644ffda72c> <http://xmlns.com/foaf/0.1/familyName> "Tachtsidis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-206599148012342784b9a9644ffda72c> <http://xmlns.com/foaf/0.1/name> "Ilias Tachtsidis"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d3843371b4c94eedada80c0c900a4c74> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d3843371b4c94eedada80c0c900a4c74> <http://xmlns.com/foaf/0.1/givenName> "Felix"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d3843371b4c94eedada80c0c900a4c74> <http://xmlns.com/foaf/0.1/familyName> "Hsieh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d3843371b4c94eedada80c0c900a4c74> <http://xmlns.com/foaf/0.1/name> "Felix Hsieh"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8574835c81c3c358b7ea1bc7231f3c9b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8574835c81c3c358b7ea1bc7231f3c9b> <http://xmlns.com/foaf/0.1/givenName> "Luca"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8574835c81c3c358b7ea1bc7231f3c9b> <http://xmlns.com/foaf/0.1/familyName> "Giannoni"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8574835c81c3c358b7ea1bc7231f3c9b> <http://xmlns.com/foaf/0.1/name> "Luca Giannoni"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e9c33d3c96bf9e69fd597f57e4cba73> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1e9c33d3c96bf9e69fd597f57e4cba73> <http://xmlns.com/foaf/0.1/givenName> "Daniel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e9c33d3c96bf9e69fd597f57e4cba73> <http://xmlns.com/foaf/0.1/familyName> "Rueckert"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1e9c33d3c96bf9e69fd597f57e4cba73> <http://xmlns.com/foaf/0.1/name> "Daniel Rueckert"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-30914a32460173d22241ca8751a932f5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-30914a32460173d22241ca8751a932f5> <http://xmlns.com/foaf/0.1/givenName> "Bruno"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-30914a32460173d22241ca8751a932f5> <http://xmlns.com/foaf/0.1/familyName> "Montcel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-30914a32460173d22241ca8751a932f5> <http://xmlns.com/foaf/0.1/name> "Bruno Montcel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e561ba802d45442277f4ba090fe99b05> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e561ba802d45442277f4ba090fe99b05> <http://xmlns.com/foaf/0.1/givenName> "Suprosanna"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e561ba802d45442277f4ba090fe99b05> <http://xmlns.com/foaf/0.1/familyName> "Shit"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e561ba802d45442277f4ba090fe99b05> <http://xmlns.com/foaf/0.1/name> "Suprosanna Shit"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5df4d55ccd7cc0e876f9534feda88c40> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5df4d55ccd7cc0e876f9534feda88c40> <http://xmlns.com/foaf/0.1/givenName> "Frédéric"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5df4d55ccd7cc0e876f9534feda88c40> <http://xmlns.com/foaf/0.1/familyName> "Lange"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5df4d55ccd7cc0e876f9534feda88c40> <http://xmlns.com/foaf/0.1/name> "Frédéric Lange"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1858aa7e9f3975d4fbd4a59aa28e43c1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1858aa7e9f3975d4fbd4a59aa28e43c1> <http://xmlns.com/foaf/0.1/givenName> "Kevin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1858aa7e9f3975d4fbd4a59aa28e43c1> <http://xmlns.com/foaf/0.1/familyName> "Scibilia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1858aa7e9f3975d4fbd4a59aa28e43c1> <http://xmlns.com/foaf/0.1/name> "Kevin Scibilia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33fbfa7b3a425a2b373d11a0b4143bef> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-33fbfa7b3a425a2b373d11a0b4143bef> <http://xmlns.com/foaf/0.1/givenName> "Ivan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33fbfa7b3a425a2b373d11a0b4143bef> <http://xmlns.com/foaf/0.1/familyName> "Iliash"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-33fbfa7b3a425a2b373d11a0b4143bef> <http://xmlns.com/foaf/0.1/name> "Ivan Iliash"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0db96a15ce65a63cf89aeff6691ca1f5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0db96a15ce65a63cf89aeff6691ca1f5> <http://xmlns.com/foaf/0.1/givenName> "Florian"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0db96a15ce65a63cf89aeff6691ca1f5> <http://xmlns.com/foaf/0.1/familyName> "Kofler"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0db96a15ce65a63cf89aeff6691ca1f5> <http://xmlns.com/foaf/0.1/name> "Florian Kofler"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10d14544321bb72c74d375c2ab998ef3> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-10d14544321bb72c74d375c2ab998ef3> <http://xmlns.com/foaf/0.1/givenName> "Ivan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-10d14544321bb72c74d375c2ab998ef3> <http://xmlns.com/foaf/0.1/familyName> "Ezhov"^^<http://www.w3.org/2001/XMLSchema#string> .
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