eprintid: 10196891 rev_number: 13 eprint_status: archive userid: 699 dir: disk0/10/19/68/91 datestamp: 2024-09-12 15:33:07 lastmod: 2025-02-18 16:39:52 status_changed: 2025-02-18 16:39:52 type: article metadata_visibility: show sword_depositor: 699 creators_name: Mirza, Laaeba creators_name: Steventon, Luke creators_name: Roylance, Rebecca creators_name: Hughes, Chantelle creators_name: Creed, Chiara creators_name: Morris, Emma creators_name: Purcell, Ian creators_name: Frank, Suzanne creators_name: Masters, Neil creators_name: Chambers, Pinkie title: Regional differences in neo/adjuvant chemotherapy timing in patients with early-stage triple negative breast cancer in England ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 keywords: Cancer, Breast, Triple-negative, Surgery, Chemotherapy, Delay note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Purpose Triple-negative breast cancer (TNBC) is an aggressive breast cancer histological type that is predictive of poor outcomes, shorter remission periods and reduced survival. TNBC is treated with surgery and neo/adjuvant chemotherapy, with evidence of association between longer periods from surgery to adjuvant chemotherapy (time to chemotherapy, TTC) and poorer survival outcomes. This study investigated regional differences in TTC period between regions and ethnic groups to evaluate equity of care in the English TNBC population. Time from neoadjuvant chemotherapy to surgery (time to surgery, TTS) was also compared between groups. Methods This retrospective cohort study compared TTC and TTS periods in TNBC patients in England over a two-year period. TTC and TTS were compared by English region and ethnicity, testing for significant differences in treatment pathway timing by these demographics. Results 1347 TNBC patients were included in the study. Significant regional differences in TTC were observed, with the longest median period of 50 days (IQR 36, 83) in the Midlands compared to 38 days (IQR 27, 55) in the North West (p < 0.001). No significant differences in TTS were observed between regions. Ethnicity was not significantly associated with timeliness of neo/adjuvant chemotherapy initiation (p > 0.05). Conclusion These findings suggest regional differences in TTC for patients treated with surgery and chemotherapy for TNBC. Given evidence of increased mortality risk as the TTC period increases, the causes of regional disparities warrant further investigation. This study can inform targets for improvement in the delivery of adjuvant chemotherapy in cancer treatment centres in England. date: 2025-01-01 date_type: published publisher: Springer Verlag official_url: https://doi.org/10.1007/s10549-024-07480-x full_text_type: other language: eng verified: verified_manual elements_id: 2311830 doi: 10.1007/s10549-024-07480-x lyricists_name: Steventon, Luke lyricists_id: LOSTE29 actors_name: Steventon, Luke actors_name: Robertson, Victoria actors_id: LOSTE29 actors_id: VROBE74 actors_role: owner actors_role: impersonator full_text_status: restricted publication: Breast Cancer Research and Treatment volume: 209 pagerange: 139-146 citation: Mirza, Laaeba; Steventon, Luke; Roylance, Rebecca; Hughes, Chantelle; Creed, Chiara; Morris, Emma; Purcell, Ian; ... Chambers, Pinkie; + view all <#> Mirza, Laaeba; Steventon, Luke; Roylance, Rebecca; Hughes, Chantelle; Creed, Chiara; Morris, Emma; Purcell, Ian; Frank, Suzanne; Masters, Neil; Chambers, Pinkie; - view fewer <#> (2025) Regional differences in neo/adjuvant chemotherapy timing in patients with early-stage triple negative breast cancer in England. Breast Cancer Research and Treatment , 209 pp. 139-146. 10.1007/s10549-024-07480-x <https://doi.org/10.1007/s10549-024-07480-x>. document_url: https://discovery.ucl.ac.uk/id/eprint/10196891/2/Steventon_TNBC%20Manuscript%20clean%2030JUL24.pdf