eprintid: 10196848
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/19/68/48
datestamp: 2024-09-12 09:29:07
lastmod: 2024-09-12 09:29:07
status_changed: 2024-09-12 09:29:07
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Hussein, Mohammad
creators_name: Angerud, Agnes
creators_name: Saez, Jordi
creators_name: Bogaert, Evelien
creators_name: Lemire, Matthieu
creators_name: Barry, Miriam
creators_name: Patallo, Ileana Silvestre
creators_name: Shipley, David
creators_name: Clark, Catharine H
creators_name: Hernandez, Victor
title: Improving the modelling of a multi-leaf collimator with tilted leaf sides used in radiotherapy
ispublished: pub
divisions: UCL
divisions: B04
divisions: F42
keywords: MLC modelling, TPS modelling, TPS commissioning
note: © 2024 The Author(s). Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology Under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/).
abstract: BACKGROUND AND PURPOSE: Multi-leaf collimators (MLCs) with tilted leaf sides have a complex transmission behaviour that is not easily matched by radiotherapy treatment planning systems (TPSs). We sought to develop an MLC model that can accurately match test fields and clinically relevant plans at different centres. MATERIALS AND METHODS: Two new MLC models were developed and evaluated within a research version of a commercial TPS. Prototype I used adjusted-constant transmissions and Prototype II used variable transmissions at the tongue-and-groove and leaf-tip regions. Three different centres evaluated these prototypes for a tilted MLC and compared them with their initial MLC model using test fields and patient-specific quality-assurance measurements of clinically relevant plans. For the latter, gamma passing rates (GPR) at 2 %/2mm were recorded. RESULTS: For the prototypes the same set of MLC parameters could be used at all centres, with only a slight adjustment of the offset parameter. For centres A and C, average GPR were >95 % and within 0.5 % GPR difference between the standard, and prototype models. In center B, prototypes I and II improved the agreement in clinically relevant plans, with an increase in GPR of 2.3 % ± 0.8 % and 3.0 ± 0.8 %, respectively. CONCLUSIONS: The prototype MLC models were either similar or superior to the initial MLC model, and simpler to configure because fewer trade-offs were required. Prototype I performed comparably to the more sophisticated Prototype II and its configuration can be easily standardized, which can be useful to reduce variability and improve safety in clinical practice.
date: 2024-01
date_type: published
publisher: ELSEVIER
official_url: http://dx.doi.org/10.1016/j.phro.2024.100543
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2276825
doi: 10.1016/j.phro.2024.100543
medium: Electronic-eCollection
pii: S2405-6316(24)00013-7
lyricists_name: Clark, Catharine
lyricists_name: Silvestre Patallo, Ileana
lyricists_id: CCLAR52
lyricists_id: ISILV85
actors_name: Silvestre Patallo, Ileana
actors_id: ISILV85
actors_role: owner
funding_acknowledgements: [National Measurement System of the UK's Department for Science, Innovation and Technology]
full_text_status: public
publication: Physics and Imaging in Radiation Oncology
volume: 29
article_number: 100543
pages: 6
event_location: Netherlands
citation:        Hussein, Mohammad;    Angerud, Agnes;    Saez, Jordi;    Bogaert, Evelien;    Lemire, Matthieu;    Barry, Miriam;    Patallo, Ileana Silvestre;             ... Hernandez, Victor; + view all <#>        Hussein, Mohammad;  Angerud, Agnes;  Saez, Jordi;  Bogaert, Evelien;  Lemire, Matthieu;  Barry, Miriam;  Patallo, Ileana Silvestre;  Shipley, David;  Clark, Catharine H;  Hernandez, Victor;   - view fewer <#>    (2024)    Improving the modelling of a multi-leaf collimator with tilted leaf sides used in radiotherapy.                   Physics and Imaging in Radiation Oncology , 29     , Article 100543.  10.1016/j.phro.2024.100543 <https://doi.org/10.1016/j.phro.2024.100543>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10196848/1/Improving%20the%20modelling%20of%20a%20multi-leaf%20collimator%20with%20tilted%20leaf%20sides%20used%20in%20radiotherapy.pdf