eprintid: 10196186
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/19/61/86
datestamp: 2024-08-27 12:56:15
lastmod: 2024-08-27 12:56:15
status_changed: 2024-08-27 12:56:15
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Vivarelli, Marina
creators_name: Barratt, Jonathan
creators_name: Beck Jr, Laurence H
creators_name: Fakhouri, Fadi
creators_name: Gale, Daniel P
creators_name: Goicoechea de Jorge, Elena
creators_name: Mosca, Marta
creators_name: Noris, Marina
creators_name: Pickering, Matthew C
creators_name: Susztak, Katalin
creators_name: Thurman, Joshua M
creators_name: Cheung, Michael
creators_name: King, Jennifer M
creators_name: Jadoul, Michel
creators_name: Winkelmayer, Wolfgang C
creators_name: Smith, Richard JH
title: The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G93
keywords: Complement inhibitor; complement-mediated injury; glomerular injury
note: Copyright  © 2024 Kidney Disease: Improving Global Outcomes (KDIGO). Published by
Elsevier Inc. on behalf of the International Society of Nephrology. This is an
open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
abstract: Uncontrolled complement activation can cause or contribute to glomerular injury in multiple kidney diseases. Although complement activation plays a causal role in atypical hemolytic uremic syndrome and C3 glomerulopathy, over the past decade, a rapidly accumulating body of evidence has shown a role for complement activation in multiple other kidney diseases, including diabetic nephropathy and several glomerulonephritides. The number of available complement inhibitor therapies has also increased during the same period. In 2022, Kidney Diseases: Improving Global Outcomes (KDIGO) convened a Controversies Conference, “The Role of Complement in Kidney Disease,” to address the expanding role of complement dysregulation in the pathophysiology, diagnosis, and management of various glomerular diseases, diabetic nephropathy, and other forms of hemolytic uremic syndrome. Conference participants reviewed the evidence for complement playing a primary causal or secondary role in progression for several disease states and considered how evidence of complement involvement might inform management. Participating patients with various complement-mediated diseases and caregivers described concerns related to life planning, implications surrounding genetic testing, and the need for inclusive implementation of effective novel therapies into clinical practice. The value of biomarkers in monitoring disease course and the role of the glomerular microenvironment in complement response were examined, and key gaps in knowledge and research priorities were identified.
date: 2024-09
date_type: published
publisher: Elsevier BV
official_url: http://dx.doi.org/10.1016/j.kint.2024.05.015
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2285101
doi: 10.1016/j.kint.2024.05.015
medium: Print-Electronic
pii: S0085-2538(24)00389-2
lyricists_name: Gale, Daniel
lyricists_id: DGALE18
actors_name: Gale, Daniel
actors_id: DGALE18
actors_role: owner
full_text_status: public
publication: Kidney International
volume: 106
number: 3
pagerange: 369-391
event_location: United States
issn: 0085-2538
citation:        Vivarelli, Marina;    Barratt, Jonathan;    Beck Jr, Laurence H;    Fakhouri, Fadi;    Gale, Daniel P;    Goicoechea de Jorge, Elena;    Mosca, Marta;                                     ... Smith, Richard JH; + view all <#>        Vivarelli, Marina;  Barratt, Jonathan;  Beck Jr, Laurence H;  Fakhouri, Fadi;  Gale, Daniel P;  Goicoechea de Jorge, Elena;  Mosca, Marta;  Noris, Marina;  Pickering, Matthew C;  Susztak, Katalin;  Thurman, Joshua M;  Cheung, Michael;  King, Jennifer M;  Jadoul, Michel;  Winkelmayer, Wolfgang C;  Smith, Richard JH;   - view fewer <#>    (2024)    The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.                   Kidney International , 106  (3)   pp. 369-391.    10.1016/j.kint.2024.05.015 <https://doi.org/10.1016/j.kint.2024.05.015>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10196186/1/Gale_1-s2.0-S0085253824003892-main.pdf