TY  - JOUR
TI  - The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
AV  - public
Y1  - 2024/09//
EP  - 391
N2  - Uncontrolled complement activation can cause or contribute to glomerular injury in multiple kidney diseases. Although complement activation plays a causal role in atypical hemolytic uremic syndrome and C3 glomerulopathy, over the past decade, a rapidly accumulating body of evidence has shown a role for complement activation in multiple other kidney diseases, including diabetic nephropathy and several glomerulonephritides. The number of available complement inhibitor therapies has also increased during the same period. In 2022, Kidney Diseases: Improving Global Outcomes (KDIGO) convened a Controversies Conference, ?The Role of Complement in Kidney Disease,? to address the expanding role of complement dysregulation in the pathophysiology, diagnosis, and management of various glomerular diseases, diabetic nephropathy, and other forms of hemolytic uremic syndrome. Conference participants reviewed the evidence for complement playing a primary causal or secondary role in progression for several disease states and considered how evidence of complement involvement might inform management. Participating patients with various complement-mediated diseases and caregivers described concerns related to life planning, implications surrounding genetic testing, and the need for inclusive implementation of effective novel therapies into clinical practice. The value of biomarkers in monitoring disease course and the role of the glomerular microenvironment in complement response were examined, and key gaps in knowledge and research priorities were identified.
ID  - discovery10196186
PB  - Elsevier BV
KW  - Complement inhibitor; complement-mediated injury; glomerular injury
VL  - 106
SP  - 369
IS  - 3
N1  - Copyright  © 2024 Kidney Disease: Improving Global Outcomes (KDIGO). Published by
Elsevier Inc. on behalf of the International Society of Nephrology. This is an
open access article under the CC BY-NC-ND license (http://
creativecommons.org/licenses/by-nc-nd/4.0/).
UR  - http://dx.doi.org/10.1016/j.kint.2024.05.015
SN  - 0085-2538
JF  - Kidney International
A1  - Vivarelli, Marina
A1  - Barratt, Jonathan
A1  - Beck Jr, Laurence H
A1  - Fakhouri, Fadi
A1  - Gale, Daniel P
A1  - Goicoechea de Jorge, Elena
A1  - Mosca, Marta
A1  - Noris, Marina
A1  - Pickering, Matthew C
A1  - Susztak, Katalin
A1  - Thurman, Joshua M
A1  - Cheung, Michael
A1  - King, Jennifer M
A1  - Jadoul, Michel
A1  - Winkelmayer, Wolfgang C
A1  - Smith, Richard JH
ER  -