eprintid: 10196058 rev_number: 8 eprint_status: archive userid: 699 dir: disk0/10/19/60/58 datestamp: 2024-08-22 09:37:38 lastmod: 2024-08-22 09:37:58 status_changed: 2024-08-22 09:37:38 type: article metadata_visibility: show sword_depositor: 699 creators_name: Sridharan, Nivetha creators_name: Salem, Ahmed creators_name: Little, Ross A creators_name: Tariq, Maira creators_name: Cheung, Susan creators_name: Dubec, Michael J creators_name: Faivre-Finn, Corinne creators_name: Parker, Geoffrey JM creators_name: Porta, Nuria creators_name: O'Connor, James PB title: Measuring repeatability of dynamic contrast-enhanced MRI biomarkers improves evaluation of biological response to radiotherapy in lung cancer ispublished: inpress divisions: UCL divisions: B04 divisions: F42 keywords: Biomarkers; Magnetic resonance imaging; Lung neoplasms; Statistics note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. abstract: Objectives: To measure dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) biomarker repeatability in patients with non-small cell lung cancer (NSCLC). To use these statistics to identify which individual target lesions show early biological response. // Materials and methods: A single-centre, prospective DCE-MRI study was performed between September 2015 and April 2017. Patients with NSCLC were scanned before standard-of-care radiotherapy to evaluate biomarker repeatability and two weeks into therapy to evaluate biological response. Volume transfer constant (Ktrans), extravascular extracellular space volume fraction (ve) and plasma volume fraction (vp) were measured at each timepoint along with tumour volume. Repeatability was assessed using a within-subject coefficient of variation (wCV) and repeatability coefficient (RC). Cohort treatment effects on biomarkers were estimated using mixed-effects models. RC limits of agreement revealed which individual target lesions changed beyond that expected with biomarker daily variation. // Results: Fourteen patients (mean age, 67 years +/− 12, 8 men) had 22 evaluable lesions (12 primary tumours, 8 nodal metastases, 2 distant metastases). The wCV (in 8/14 patients) was between 9.16% to 17.02% for all biomarkers except for vp, which was 42.44%. Cohort-level changes were significant for Ktrans and ve (p < 0.001) and tumour volume (p = 0.002). Ktrans and tumour volume consistently showed the greatest number of individual lesions showing biological response. In distinction, no individual lesions had a real change in ve despite the cohort-level change. // Conclusion: Identifying individual early biological responders provided additional information to that derived from conventional cohort cohort-level statistics, helping to prioritise which parameters would be best taken forward into future studies. date: 2024-08-09 date_type: published publisher: SPRINGER official_url: http://dx.doi.org/10.1007/s00330-024-10970-7 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2306262 doi: 10.1007/s00330-024-10970-7 lyricists_name: Parker, Geoffrey lyricists_id: GPARK63 actors_name: Parker, Geoffrey actors_id: GPARK63 actors_role: owner funding_acknowledgements: C19221/A28683 [Cancer Research UK NCITA grant]; C1491/A25351 [Cancer Research UK]; C19221/A15267 [Cancer Research UK]; [Clinician Scientist Fellowship from Cancer Research UK]; [National Institute for Health Research (NIHR) Biomedical Research Centre at The Royal Marsden NHS Foundation Trust]; NIHR203314 [Institute of Cancer Research, London] full_text_status: public publication: European Radiology pages: 10 issn: 0938-7994 citation: Sridharan, Nivetha; Salem, Ahmed; Little, Ross A; Tariq, Maira; Cheung, Susan; Dubec, Michael J; Faivre-Finn, Corinne; ... O'Connor, James PB; + view all <#> Sridharan, Nivetha; Salem, Ahmed; Little, Ross A; Tariq, Maira; Cheung, Susan; Dubec, Michael J; Faivre-Finn, Corinne; Parker, Geoffrey JM; Porta, Nuria; O'Connor, James PB; - view fewer <#> (2024) Measuring repeatability of dynamic contrast-enhanced MRI biomarkers improves evaluation of biological response to radiotherapy in lung cancer. European Radiology 10.1007/s00330-024-10970-7 <https://doi.org/10.1007/s00330-024-10970-7>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10196058/1/Sridharan%20et%20al.%20-%202024%20-%20Measuring%20repeatability%20of%20dynamic%20contrast-enhanc.pdf