eprintid: 10195638 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/19/56/38 datestamp: 2024-08-12 11:06:28 lastmod: 2024-08-12 11:06:28 status_changed: 2024-08-12 11:06:28 type: article metadata_visibility: show sword_depositor: 699 creators_name: Allen, NE creators_name: Lacey, B creators_name: Lawlor, DA creators_name: Pell, JP creators_name: Gallacher, J creators_name: Smeeth, L creators_name: Elliott, P creators_name: Matthews, PM creators_name: Lyons, RA creators_name: Whetton, AD creators_name: Lucassen, A creators_name: Hurles, ME creators_name: Chapman, M creators_name: Roddam, AW creators_name: Fitzpatrick, NK creators_name: Hansell, AL creators_name: Hardy, R creators_name: Marioni, RE creators_name: O'Donnell, VB creators_name: Williams, J creators_name: Lindgren, CM creators_name: Effingham, M creators_name: Sellors, J creators_name: Danesh, J creators_name: Collins, R title: Prospective study design and data analysis in UK Biobank ispublished: pub divisions: UCL divisions: B16 divisions: B02 divisions: B14 divisions: J81 divisions: DD4 divisions: J73 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide. date: 2024-01-10 date_type: published publisher: American Association for the Advancement of Science official_url: https://doi.org/10.1126/scitranslmed.adf4428 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2140723 doi: 10.1126/scitranslmed.adf4428 medium: Print-Electronic lyricists_name: Hardy, Rebecca lyricists_name: Fitzpatrick, Natalie lyricists_id: RHARD63 lyricists_id: NKBOS44 actors_name: Fitzpatrick, Natalie actors_id: NKBOS44 actors_role: owner funding_acknowledgements: [Mrc, wellcome]; [British Heart Foundation]; [Cancer research UK]; [National institute for Health research] full_text_status: public publication: Science Translational Medicine volume: 16 number: 729 article_number: eadf4428 event_location: United States issn: 1946-6234 citation: Allen, NE; Lacey, B; Lawlor, DA; Pell, JP; Gallacher, J; Smeeth, L; Elliott, P; ... Collins, R; + view all <#> Allen, NE; Lacey, B; Lawlor, DA; Pell, JP; Gallacher, J; Smeeth, L; Elliott, P; Matthews, PM; Lyons, RA; Whetton, AD; Lucassen, A; Hurles, ME; Chapman, M; Roddam, AW; Fitzpatrick, NK; Hansell, AL; Hardy, R; Marioni, RE; O'Donnell, VB; Williams, J; Lindgren, CM; Effingham, M; Sellors, J; Danesh, J; Collins, R; - view fewer <#> (2024) Prospective study design and data analysis in UK Biobank. Science Translational Medicine , 16 (729) , Article eadf4428. 10.1126/scitranslmed.adf4428 <https://doi.org/10.1126/scitranslmed.adf4428>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10195638/1/nihms-1988190.pdf