TY - JOUR VL - 16 N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. PB - American Association for the Advancement of Science A1 - Allen, NE A1 - Lacey, B A1 - Lawlor, DA A1 - Pell, JP A1 - Gallacher, J A1 - Smeeth, L A1 - Elliott, P A1 - Matthews, PM A1 - Lyons, RA A1 - Whetton, AD A1 - Lucassen, A A1 - Hurles, ME A1 - Chapman, M A1 - Roddam, AW A1 - Fitzpatrick, NK A1 - Hansell, AL A1 - Hardy, R A1 - Marioni, RE A1 - O'Donnell, VB A1 - Williams, J A1 - Lindgren, CM A1 - Effingham, M A1 - Sellors, J A1 - Danesh, J A1 - Collins, R JF - Science Translational Medicine AV - public Y1 - 2024/01/10/ SN - 1946-6234 TI - Prospective study design and data analysis in UK Biobank UR - https://doi.org/10.1126/scitranslmed.adf4428 ID - discovery10195638 N2 - Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide. IS - 729 ER -