TY - CHAP Y1 - 2024/// M1 - 53 N2 - We study the solution of integrated planning and scheduling problems that are formulated as bilevel programming problems with mixed-integer nonlinear lower levels using data-driven optimization algorithms. Due to their inherent interdependence, multi-scale nature, and volatile market conditions, decision-making in such multi-level supply chain networks poses challenging task. Traditionally, these problems are addressed sequentially but, this approach often results in production schedules that are not feasible. Motivated by this, we formulate enterprise-wide decision-making problems with linear production planning and mixed-integer nonlinear scheduling level as a bilevel optimization problem. We solve the resulting integrated problem using the DOMINO framework which is a data-driven optimization strategy to handle general constrained bilevel optimization problems. We demonstrate our approach on case studies with varying complexities from crude oil scheduling using a continuous-time formulation to scheduling of continuous manufacturing processes using a traveling salesman problem formulation. The results show that DOMINO can address bilevel programming problems with high-dimensional mixed-integer nonlinear lower levels and can be applied to complex integrated enterprise-wide optimization problems, regardless of the lower-level formulation type. T3 - Computer Aided Chemical Engineering UR - http://dx.doi.org/10.1016/b978-0-443-28824-1.50319-7 ID - discovery10194769 SP - 1909 A1 - Nikkhah, Hasan A1 - Charitopoulos, Vassilis M A1 - Avraamidou, Styliani A1 - Beykal, Burcu PB - Elsevier ED - Manenti, Flavio ED - Reklaitis, Gintaras V CY - Amsterdam, The Netherlands TI - Bilevel optimization of mixed-integer nonlinear integrated planning and scheduling problems using the DOMINO framework AV - restricted T2 - Computer Aided Chemical Engineering EP - 1914 N1 - This version is the version of record. For information on re-use, please refer to the publisher?s terms and conditions. KW - Data-driven optimization KW - mixed-integer nonlinear programming KW - bilevel programming KW - enterprise-wide optimization KW - production planning KW - scheduling. ER -