<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10194363> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/title> "Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/abstract> "Alpha-1 antitrypsin deficiency (A1ATD) is a life-threatening condition caused by inheritance of the SERPINA1 ‘Z’ genetic variant (PiZ) driving AAT protein misfolding in hepatocytes. There remain no approved medicines for this disease. Here, we report the results of a small molecule screen performed in patient derived iPSC-hepatocytes that identified Leucine-rich repeat kinase-2 (LRRK2) as a potentially new therapeutic target. Of the commercially available LRRK2 inhibitors tested, we identified CZC-25146, a candidate with favorable pharmacokinetic properties, as being capable of reducing polymer load, increasing normal AAT secretion, and reducing inflammatory cytokines in both cells and PiZ mice. Mechanistically, this effect was achieved through induction of autophagy. Our findings support the use of CZC-25146 and LRRK2 inhibitors in hepatic proteinopathy research and their further investigation as novel therapeutic candidates for A1ATD."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/date> "2024-07-02" . <https://discovery.ucl.ac.uk/id/document/1755644> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/org/ext-79b4a019fe89cabb0b3404e08dd2bf9f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-79b4a019fe89cabb0b3404e08dd2bf9f> <http://xmlns.com/foaf/0.1/name> "Ovid Technologies (Wolters Kluwer Health)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-79b4a019fe89cabb0b3404e08dd2bf9f> . <https://discovery.ucl.ac.uk/id/publication/ext-02709139> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-02709139> <http://xmlns.com/foaf/0.1/name> "Hepatology"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-02709139> . <https://discovery.ucl.ac.uk/id/publication/ext-02709139> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:02709139> . <https://discovery.ucl.ac.uk/id/publication/ext-02709139> <http://purl.org/ontology/bibo/issn> "02709139" . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/forthcoming> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3cb931369283bc9ff8fe9093ce3e5902> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-3cb931369283bc9ff8fe9093ce3e5902> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3d8d935f65adb042a35e8dbe35ff53b3> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-3d8d935f65adb042a35e8dbe35ff53b3> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2135f4d7758532795f29b2aa488467e1> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-2135f4d7758532795f29b2aa488467e1> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c81adb8fda95caa9593e564c54f99e3d> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-c81adb8fda95caa9593e564c54f99e3d> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f4e47485fc7ad52cc698abeb0039b593> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-f4e47485fc7ad52cc698abeb0039b593> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b4e442d2a8b0d2b45d82801598b94d5f> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-b4e442d2a8b0d2b45d82801598b94d5f> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1125fe57ce4a206fae2eae27bd8b4384> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-1125fe57ce4a206fae2eae27bd8b4384> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fbb5c42666e1d4a0820ede53b4c36455> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-fbb5c42666e1d4a0820ede53b4c36455> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f82bcf74038eda5999973b4133226a10> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-f82bcf74038eda5999973b4133226a10> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-49c3a4dc60c71a3c4ebcde08dfe998ca> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-49c3a4dc60c71a3c4ebcde08dfe998ca> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e68683aded9f93ea9183134b2587c7bd> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e68683aded9f93ea9183134b2587c7bd> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e7bc49275127ce6a568bf4b72753f350> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-e7bc49275127ce6a568bf4b72753f350> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-52cc21e11a2585b0536fc0d6d25b00cc> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-52cc21e11a2585b0536fc0d6d25b00cc> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1d5e7fb10e97bc32d161318014323c5d> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-1d5e7fb10e97bc32d161318014323c5d> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b070ca1eced531ba5b1aa28c53f2186a> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-b070ca1eced531ba5b1aa28c53f2186a> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f5f7878ebce929ba896b5d9c6a876a8c> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-f5f7878ebce929ba896b5d9c6a876a8c> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1b42512745e583e713179550470a7438> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-1b42512745e583e713179550470a7438> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4266939de15021874bf32f5fbbf089ce> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_18> <https://discovery.ucl.ac.uk/id/person/ext-4266939de15021874bf32f5fbbf089ce> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-827842da7f657f66ea5dd2afa9a82645> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_19> <https://discovery.ucl.ac.uk/id/person/ext-827842da7f657f66ea5dd2afa9a82645> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7137fe3aa920a3788c442f4b8cc45a9a> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_20> <https://discovery.ucl.ac.uk/id/person/ext-7137fe3aa920a3788c442f4b8cc45a9a> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-56b080035224cedcf3c12b81139a194e> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_21> <https://discovery.ucl.ac.uk/id/person/ext-56b080035224cedcf3c12b81139a194e> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1c318ae62673945592c4b823722f3b08> . <https://discovery.ucl.ac.uk/id/eprint/10194363> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> . <https://discovery.ucl.ac.uk/id/eprint/10194363#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_22> <https://discovery.ucl.ac.uk/id/person/ext-1c318ae62673945592c4b823722f3b08> . <https://discovery.ucl.ac.uk/id/person/ext-1125fe57ce4a206fae2eae27bd8b4384> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1125fe57ce4a206fae2eae27bd8b4384> <http://xmlns.com/foaf/0.1/givenName> "Marina"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1125fe57ce4a206fae2eae27bd8b4384> <http://xmlns.com/foaf/0.1/familyName> "Zieger"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1125fe57ce4a206fae2eae27bd8b4384> <http://xmlns.com/foaf/0.1/name> "Marina Zieger"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f5f7878ebce929ba896b5d9c6a876a8c> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f5f7878ebce929ba896b5d9c6a876a8c> <http://xmlns.com/foaf/0.1/givenName> "Patrick A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f5f7878ebce929ba896b5d9c6a876a8c> <http://xmlns.com/foaf/0.1/familyName> "Lewis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f5f7878ebce929ba896b5d9c6a876a8c> <http://xmlns.com/foaf/0.1/name> "Patrick A Lewis"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b4e442d2a8b0d2b45d82801598b94d5f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-b4e442d2a8b0d2b45d82801598b94d5f> <http://xmlns.com/foaf/0.1/givenName> "Chao Zheng"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b4e442d2a8b0d2b45d82801598b94d5f> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-b4e442d2a8b0d2b45d82801598b94d5f> <http://xmlns.com/foaf/0.1/name> "Chao Zheng Li"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2135f4d7758532795f29b2aa488467e1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-2135f4d7758532795f29b2aa488467e1> <http://xmlns.com/foaf/0.1/givenName> "Adam M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2135f4d7758532795f29b2aa488467e1> <http://xmlns.com/foaf/0.1/familyName> "Syanda"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-2135f4d7758532795f29b2aa488467e1> <http://xmlns.com/foaf/0.1/name> "Adam M Syanda"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f82bcf74038eda5999973b4133226a10> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f82bcf74038eda5999973b4133226a10> <http://xmlns.com/foaf/0.1/givenName> "Stephanie"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f82bcf74038eda5999973b4133226a10> <http://xmlns.com/foaf/0.1/familyName> "Hatch"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f82bcf74038eda5999973b4133226a10> <http://xmlns.com/foaf/0.1/name> "Stephanie Hatch"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7137fe3aa920a3788c442f4b8cc45a9a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-7137fe3aa920a3788c442f4b8cc45a9a> <http://xmlns.com/foaf/0.1/givenName> "Daniel"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7137fe3aa920a3788c442f4b8cc45a9a> <http://xmlns.com/foaf/0.1/familyName> "Ebner"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-7137fe3aa920a3788c442f4b8cc45a9a> <http://xmlns.com/foaf/0.1/name> "Daniel Ebner"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-56b080035224cedcf3c12b81139a194e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-56b080035224cedcf3c12b81139a194e> <http://xmlns.com/foaf/0.1/givenName> "Christian"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-56b080035224cedcf3c12b81139a194e> <http://xmlns.com/foaf/0.1/familyName> "Mueller"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-56b080035224cedcf3c12b81139a194e> <http://xmlns.com/foaf/0.1/name> "Christian Mueller"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4266939de15021874bf32f5fbbf089ce> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-4266939de15021874bf32f5fbbf089ce> <http://xmlns.com/foaf/0.1/givenName> "Sunil"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4266939de15021874bf32f5fbbf089ce> <http://xmlns.com/foaf/0.1/familyName> "Sahdeo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-4266939de15021874bf32f5fbbf089ce> <http://xmlns.com/foaf/0.1/name> "Sunil Sahdeo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1c318ae62673945592c4b823722f3b08> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1c318ae62673945592c4b823722f3b08> <http://xmlns.com/foaf/0.1/givenName> "S Tamir"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1c318ae62673945592c4b823722f3b08> <http://xmlns.com/foaf/0.1/familyName> "Rashid"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1c318ae62673945592c4b823722f3b08> <http://xmlns.com/foaf/0.1/name> "S Tamir Rashid"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3cb931369283bc9ff8fe9093ce3e5902> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-3cb931369283bc9ff8fe9093ce3e5902> <http://xmlns.com/foaf/0.1/givenName> "Deniz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3cb931369283bc9ff8fe9093ce3e5902> <http://xmlns.com/foaf/0.1/familyName> "Kent"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-3cb931369283bc9ff8fe9093ce3e5902> <http://xmlns.com/foaf/0.1/name> "Deniz Kent"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7bc49275127ce6a568bf4b72753f350> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e7bc49275127ce6a568bf4b72753f350> <http://xmlns.com/foaf/0.1/givenName> "Yu Ri"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7bc49275127ce6a568bf4b72753f350> <http://xmlns.com/foaf/0.1/familyName> "Im"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7bc49275127ce6a568bf4b72753f350> <http://xmlns.com/foaf/0.1/name> "Yu Ri Im"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c81adb8fda95caa9593e564c54f99e3d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c81adb8fda95caa9593e564c54f99e3d> <http://xmlns.com/foaf/0.1/givenName> "Payam"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c81adb8fda95caa9593e564c54f99e3d> <http://xmlns.com/foaf/0.1/familyName> "Khoshkenar"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c81adb8fda95caa9593e564c54f99e3d> <http://xmlns.com/foaf/0.1/name> "Payam Khoshkenar"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f4e47485fc7ad52cc698abeb0039b593> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-f4e47485fc7ad52cc698abeb0039b593> <http://xmlns.com/foaf/0.1/givenName> "Riccardo"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f4e47485fc7ad52cc698abeb0039b593> <http://xmlns.com/foaf/0.1/familyName> "Ronzoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f4e47485fc7ad52cc698abeb0039b593> <http://xmlns.com/foaf/0.1/name> "Riccardo Ronzoni"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1b42512745e583e713179550470a7438> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1b42512745e583e713179550470a7438> <http://xmlns.com/foaf/0.1/givenName> "James A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1b42512745e583e713179550470a7438> <http://xmlns.com/foaf/0.1/familyName> "Irving"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1b42512745e583e713179550470a7438> <http://xmlns.com/foaf/0.1/name> "James A Irving"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e68683aded9f93ea9183134b2587c7bd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e68683aded9f93ea9183134b2587c7bd> <http://xmlns.com/foaf/0.1/givenName> "Samuel Ji"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e68683aded9f93ea9183134b2587c7bd> <http://xmlns.com/foaf/0.1/familyName> "Blackford"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e68683aded9f93ea9183134b2587c7bd> <http://xmlns.com/foaf/0.1/name> "Samuel Ji Blackford"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d5e7fb10e97bc32d161318014323c5d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-1d5e7fb10e97bc32d161318014323c5d> <http://xmlns.com/foaf/0.1/givenName> "Taylor"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d5e7fb10e97bc32d161318014323c5d> <http://xmlns.com/foaf/0.1/familyName> "Ismali"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d5e7fb10e97bc32d161318014323c5d> <http://xmlns.com/foaf/0.1/name> "Taylor Ismali"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-827842da7f657f66ea5dd2afa9a82645> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-827842da7f657f66ea5dd2afa9a82645> <http://xmlns.com/foaf/0.1/givenName> "David A"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-827842da7f657f66ea5dd2afa9a82645> <http://xmlns.com/foaf/0.1/familyName> "Lomas"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-827842da7f657f66ea5dd2afa9a82645> <http://xmlns.com/foaf/0.1/name> "David A Lomas"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-49c3a4dc60c71a3c4ebcde08dfe998ca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-49c3a4dc60c71a3c4ebcde08dfe998ca> <http://xmlns.com/foaf/0.1/givenName> "Joe"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-49c3a4dc60c71a3c4ebcde08dfe998ca> <http://xmlns.com/foaf/0.1/familyName> "Segal"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-49c3a4dc60c71a3c4ebcde08dfe998ca> <http://xmlns.com/foaf/0.1/name> "Joe Segal"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-52cc21e11a2585b0536fc0d6d25b00cc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-52cc21e11a2585b0536fc0d6d25b00cc> <http://xmlns.com/foaf/0.1/givenName> "Vivek"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-52cc21e11a2585b0536fc0d6d25b00cc> <http://xmlns.com/foaf/0.1/familyName> "Chowdary"^^<http://www.w3.org/2001/XMLSchema#string> . 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