?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Model-based+Design+of+Experiments+for+the+Identification+of+Kinetic+Models+of+Amide+Formation&rft.creator=Agunloye%2C+Emmanuel&rft.creator=Yusuf%2C+Muhammad&rft.creator=Chamberlain%2C+Thomas+W&rft.creator=Muller%2C+Frans+L&rft.creator=Bourne%2C+Richard+A&rft.creator=Galvanin%2C+Federico&rft.description=Model-based+design+of+experiments+(MBDoE)+techniques+have+been+applied+to+various+process+systems+in+the+scientific+community+to+optimally+determine+a+minimum+number+of+informative+experiments+to+enable+identification+of+a+kinetic+model+structure+with+precisely+determined+parameters.+The+effectiveness+of+MBDoE+techniques+is+however+deeply+affected+by+parametric+uncertainty.+To+evaluate+the+effect+of+parametric+uncertainty+on+model+effectiveness%2C+this+work+compares+and+evaluates+two+different+MBDoE+approaches%3A+1)+LHS-MBDoE%2C+where+the+Latin-hypercube+sampling+(LHS)+precedes+MBDoE+application%3B+and+2)+robust+MBDoE%2C+where+MBDoE+techniques+apply+ab-initio+via+either+the+expected+value+or+worst-case+approach.+Using+experimental+and+in-silico+data%2C+MBDoE+methodologies+were+tested+on+a+pharmaceutically+relevant+reaction+system+involving+homogeneous+amide+formation%2C+which+can+be+described+using+reversible+chemical+kinetics.+The+performances+of+the+two+MBDoE+approaches+were+assessed+using+i)+the&rft.subject=Amide+formation%2C+Latin-hypercube+sampling%2C+kinetic+models%2C+model-based+design+of+experiment%2C+robust+model-based+design+of+experiment&rft.publisher=Elsevier&rft.date=2024-06-03&rft.type=Proceedings+paper&rft.language=eng&rft.source=+++++In%3A++34th+European+Symposium+on+Computer+Aided+Process+Engineering+%2F15th+International+Symposium+on+Process+Systems+Engineering+ESCAPE-34%2FPSE2024.++++Elsevier%3A+Amsterdam%2C+Netherlands.+(2024)+++++&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10193576%2F