TY  - JOUR
VL  - 71
N2  - Necrotizing Enterocolitis (NEC) is a devastating condition affecting prematurely born neonates. Reviewing Abdominal X-rays (AXRs) is a key step in NEC diagnosis, staging and treatment decision-making, but poses significant challenges due to the subtle, difficult-to-identify radiological signs of the disease. In this paper, we propose AIDNEC - AI D iagnosis of NEC rotizing enterocolitis, a deep learning method to automatically detect and stratify the severity (surgical or medical) of NEC from no pathology in AXRs. The model is trainable end-to-end and integrates a Detection Transformer and Graph Convolution modules for localizing discriminative areas in AXRs, used to formulate subtle local embeddings. These are then combined with global image features to perform Fine-Grained Visual Classification (FGVC). We evaluate AIDNEC on our GOSH NEC dataset of 1153 images from 334 patients, achieving 79.7% accuracy in classifying NEC against No Pathology. AIDNEC outperforms the backbone by 2.6%, FGVC models by 2.5% and CheXNet by 4.2%, with statistically significant (two-tailed p < 0.05) improvements, while providing meaningful discriminative regions to support the classification decision. Additional validation in the publicly available Chest X-ray14 dataset yields comparable performance to state-of-the-art methods, illustrating AIDNEC's robustness in a different X-ray classification task. Dataset and source code will be released in our institutional database.
SN  - 0018-9294
EP  - 3169
Y1  - 2024/11//
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
TI  - Diagnosing Necrotising Enterocolitis Via Fine-Grained Visual Classification
IS  - 11
KW  - Necrotizing Enterocolitis
KW  -  Fine Grained Visual Classification
KW  -  Abdominal X-ray
UR  - http://dx.doi.org/10.1109/tbme.2024.3409642
A1  - Yung, Ka-Wai
A1  - Sivaraj, Jayaram
A1  - De Coppi, Paolo
A1  - Stoyanov, Danail
A1  - Loukogeorgakis, Stavros
A1  - Mazomenos, Evangelos B
AV  - public
SP  - 3160  
ID  - discovery10193306
PB  - Institute of Electrical and Electronics Engineers (IEEE)
JF  - IEEE Transactions on Biomedical Engineering
ER  -