eprintid: 10192414 rev_number: 8 eprint_status: archive userid: 699 dir: disk0/10/19/24/14 datestamp: 2024-05-16 12:06:27 lastmod: 2024-05-16 12:06:27 status_changed: 2024-05-16 12:06:27 type: article metadata_visibility: show sword_depositor: 699 creators_name: Boudreau, Mathieu creators_name: Karakuzu, Agah creators_name: Cohen-Adad, Julien creators_name: Bozkurt, Ecem creators_name: Carr, Madeline creators_name: Castellaro, Marco creators_name: Concha, Luis creators_name: Doneva, Mariya creators_name: Dual, Seraina A creators_name: Ensworth, Alex creators_name: Foias, Alexandru creators_name: Fortier, Véronique creators_name: Gabr, Refaat E creators_name: Gilbert, Guillaume creators_name: Glide-Hurst, Carri K creators_name: Grech-Sollars, Matthew creators_name: Hu, Siyuan creators_name: Jalnefjord, Oscar creators_name: Jovicich, Jorge creators_name: Keskin, Kübra creators_name: Koken, Peter creators_name: Kolokotronis, Anastasia creators_name: Kukran, Simran creators_name: Lee, Nam G creators_name: Levesque, Ives R creators_name: Li, Bochao creators_name: Ma, Dan creators_name: Mädler, Burkhard creators_name: Maforo, Nyasha G creators_name: Near, Jamie creators_name: Pasaye, Erick creators_name: Ramirez-Manzanares, Alonso creators_name: Statton, Ben creators_name: Stehning, Christian creators_name: Tambalo, Stefano creators_name: Tian, Ye creators_name: Wang, Chenyang creators_name: Weiss, Kilian creators_name: Zakariaei, Niloufar creators_name: Zhang, Shuo creators_name: Zhao, Ziwei creators_name: Stikov, Nikola creators_name: ISMRM Reproducible Research Study Group and the ISMRM Quantitati, title: Repeat it without me: Crowdsourcing the T1 mapping common ground via the ISMRM reproducibility challenge ispublished: inpress divisions: UCL divisions: B04 divisions: C05 divisions: F48 keywords: T1 mapping, inversion recovery, open data, quantitative MRI, reproducibility note: © 2024 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. abstract: PURPOSE: T1 mapping is a widely used quantitative MRI technique, but its tissue-specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research and Quantitative MR study groups jointly launched a challenge to assess the reproducibility of a well-established inversion-recovery T1 mapping technique, using acquisition details from a seminal T1 mapping paper on a standardized phantom and in human brains. METHODS: The challenge used the acquisition protocol from Barral et al. (2010). Researchers collected T1 mapping data on the ISMRM/NIST phantom and/or in human brains. Data submission, pipeline development, and analysis were conducted using open-source platforms. Intersubmission and intrasubmission comparisons were performed. RESULTS: Eighteen submissions (39 phantom and 56 human datasets) on scanners by three MRI vendors were collected at 3 T (except one, at 0.35 T). The mean coefficient of variation was 6.1% for intersubmission phantom measurements, and 2.9% for intrasubmission measurements. For humans, the intersubmission/intrasubmission coefficient of variation was 5.9/3.2% in the genu and 16/6.9% in the cortex. An interactive dashboard for data visualization was also developed: https://rrsg2020.dashboards.neurolibre.org. CONCLUSION: The T1 intersubmission variability was twice as high as the intrasubmission variability in both phantoms and human brains, indicating that the acquisition details in the original paper were insufficient to reproduce a quantitative MRI protocol. This study reports the inherent uncertainty in T1 measures across independent research groups, bringing us one step closer to a practical clinical baseline of T1 variations in vivo. date: 2024-05-10 date_type: published publisher: Wiley official_url: http://dx.doi.org/10.1002/mrm.30111 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2275025 doi: 10.1002/mrm.30111 medium: Print-Electronic lyricists_name: Grech Sollars, Matthew lyricists_id: MGREC34 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Magnetic Resonance in Medicine event_location: United States issn: 0740-3194 citation: Boudreau, Mathieu; Karakuzu, Agah; Cohen-Adad, Julien; Bozkurt, Ecem; Carr, Madeline; Castellaro, Marco; Concha, Luis; ... ISMRM Reproducible Research Study Group and the ISMRM Quantitati; + view all <#> Boudreau, Mathieu; Karakuzu, Agah; Cohen-Adad, Julien; Bozkurt, Ecem; Carr, Madeline; Castellaro, Marco; Concha, Luis; Doneva, Mariya; Dual, Seraina A; Ensworth, Alex; Foias, Alexandru; Fortier, Véronique; Gabr, Refaat E; Gilbert, Guillaume; Glide-Hurst, Carri K; Grech-Sollars, Matthew; Hu, Siyuan; Jalnefjord, Oscar; Jovicich, Jorge; Keskin, Kübra; Koken, Peter; Kolokotronis, Anastasia; Kukran, Simran; Lee, Nam G; Levesque, Ives R; Li, Bochao; Ma, Dan; Mädler, Burkhard; Maforo, Nyasha G; Near, Jamie; Pasaye, Erick; Ramirez-Manzanares, Alonso; Statton, Ben; Stehning, Christian; Tambalo, Stefano; Tian, Ye; Wang, Chenyang; Weiss, Kilian; Zakariaei, Niloufar; Zhang, Shuo; Zhao, Ziwei; Stikov, Nikola; ISMRM Reproducible Research Study Group and the ISMRM Quantitati; - view fewer <#> (2024) Repeat it without me: Crowdsourcing the T1 mapping common ground via the ISMRM reproducibility challenge. Magnetic Resonance in Medicine 10.1002/mrm.30111 <https://doi.org/10.1002/mrm.30111>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10192414/1/Repeat%20it%20without%20me%20Crowdsourcing%20the%20T1%20mapping%20common%20ground.pdf