<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10192201> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/dc/terms/title> "Mining metagenomics data for novel bacterial nanocompartments"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/ontology/bibo/abstract> "Encapsulin nanocompartments are prokaryotic protein-based organelles. T he y displa y div erse natural functions, including mineral storage and stress response. Encapsulins also ha v e applications in synthetic biology, drug deliv ery, v accines, and met abolic engineering . Disco v ering no v el encapsulins is challenging due to inconsistent annotations, and data contamination due to similarity with phage proteins. P re vious studies ha v e disco v ered thousands of encapsulin sequences from bacteria and archaea, but met agenomics dat abases were not specifically interrogated. Metagenomics can provide information on a much larger diversity of unculturable organisms and environmental samples than con v entional sequencing experiments, and metagenomic protein databases ha v e shed light on previously unexplored regions of the protein universe. This study le v erages de v elopments in deep learning for str uct ure and function prediction, to produce a dataset of o v er 1300 no v el putativ e encap- sulin sequences from the MGnify Protein Database. Some well-known encapsulins and their cargo proteins were identified, predominantly pero xidases and ferritin-lik e proteins. A potentially no v el encapsulin-associated biosynthetic gene cluster in v olv ed in producing cytoto xic or an- timicrobial saccharides was discovered using biosynthetic gene cluster prediction. Finally, a cluster of predicted str uct ures with no v el features not seen in experimentally solved encapsulin str uct ures was discovered using large-scale, deep learning-based str uct ure prediction of putative metagenomic encapsulins."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/dc/terms/date> "2024-03-07" . <https://discovery.ucl.ac.uk/id/document/1743556> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/ontology/bibo/volume> "6" . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/ontology/bibo/issue> "1" . <https://discovery.ucl.ac.uk/id/org/ext-fef0210621b463ea6872dff71124d367> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-fef0210621b463ea6872dff71124d367> <http://xmlns.com/foaf/0.1/name> "OXFORD UNIV 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<http://purl.org/ontology/bibo/status/published> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e7a6aa641789910222fb239fbf946ff9> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10192201#authors> . <https://discovery.ucl.ac.uk/id/eprint/10192201#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-e7a6aa641789910222fb239fbf946ff9> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-25dbfda7de6b7debb0fbe5d9bc760332> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10192201#authors> . <https://discovery.ucl.ac.uk/id/eprint/10192201#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> 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<http://xmlns.com/foaf/0.1/familyName> "Frank"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-f6402908b1d8344f70142b6affad65d4> <http://xmlns.com/foaf/0.1/name> "Stefanie Frank"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-25dbfda7de6b7debb0fbe5d9bc760332> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-25dbfda7de6b7debb0fbe5d9bc760332> <http://xmlns.com/foaf/0.1/givenName> "Renos"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-25dbfda7de6b7debb0fbe5d9bc760332> <http://xmlns.com/foaf/0.1/familyName> "Savva"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-25dbfda7de6b7debb0fbe5d9bc760332> <http://xmlns.com/foaf/0.1/name> "Renos Savva"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7a6aa641789910222fb239fbf946ff9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e7a6aa641789910222fb239fbf946ff9> <http://xmlns.com/foaf/0.1/givenName> "Naail"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7a6aa641789910222fb239fbf946ff9> <http://xmlns.com/foaf/0.1/familyName> "Kashif-Khan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e7a6aa641789910222fb239fbf946ff9> <http://xmlns.com/foaf/0.1/name> "Naail Kashif-Khan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10192201> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . 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