eprintid: 10191815 rev_number: 6 eprint_status: archive userid: 699 dir: disk0/10/19/18/15 datestamp: 2024-05-09 09:57:08 lastmod: 2024-05-09 09:57:08 status_changed: 2024-05-09 09:57:08 type: article metadata_visibility: show sword_depositor: 699 creators_name: Kroese, Tiuri E creators_name: Bronzwaer, Sebastiaan creators_name: van Rossum, Peter SN creators_name: Schoppman, Sebastian F creators_name: Deseyne, Pieter RAJ creators_name: van Cutsem, Eric creators_name: Haustermans, Karin creators_name: Nafteux, Philippe creators_name: Thomas, Melissa creators_name: Obermannova, Radka creators_name: Mortensen, Hanna R creators_name: Nordsmark, Marianne creators_name: Pfeiffer, Per creators_name: Elme, Anneli creators_name: Adenis, Antoine creators_name: Piessen, Guillaume creators_name: Bruns, Christiane J creators_name: Lordick, Florian creators_name: Gockel, Ines creators_name: Moehler, Markus creators_name: Gani, Cihan creators_name: Liakakos, Theodore creators_name: Reynolds, John V creators_name: Morganti, Alessio G creators_name: Rosati, Riccardo creators_name: Castoro, Carlo creators_name: Cellini, Francesco creators_name: D'Ugo, Domenico creators_name: Roviello, Franco creators_name: Bencivenga, Maria creators_name: de Manzoni, Giovanni creators_name: van Berge Henegouwen, Mark I creators_name: Hulshoff, Maarten CCM creators_name: van Dieren, Jolanda creators_name: Vollebergh, Marieke creators_name: van Sandick, Johanna W creators_name: Jeene, Paul creators_name: Muijs, Christel creators_name: Slingerland, Marije creators_name: Voncken, Francine EM creators_name: Hartgrink, Henk creators_name: Creemers, Geert-Jan creators_name: van der Sangen, Maurice JC creators_name: Nieuwenhuijzen, Grard AP creators_name: Berbee, Maaike creators_name: Verheij, Marcel creators_name: Wijnhoven, Bas creators_name: Beerepoot, Laurens V creators_name: Mohammad, Nadia Haj creators_name: Mook, Stella creators_name: Ruurda, Jelle P creators_name: Kolodziejczyk, Piotr creators_name: Polkowski, Wojciech P creators_name: Wyrwicz, Lucjan creators_name: Alsina, Maria creators_name: Tabernero, Josep creators_name: Pera, Manuel creators_name: Kanonnikoff, Tania F creators_name: Cervantes, Andrés creators_name: Nilsson, Magnus creators_name: Monig, Stefan creators_name: Wagner, Anna D creators_name: Guckenberger, Matthias creators_name: Griffiths, Ewen A creators_name: Smyth, Elizabeth creators_name: Hanna, George B creators_name: Markar, Sheraz creators_name: Chaudry, M Asif creators_name: Hawkins, Maria A creators_name: Cheong, Edward creators_name: van Laarhoven, Hanneke WM creators_name: van Hillegersberg, Richard creators_name: OMEC collaborators, title: European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4) ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F42 keywords: Esophageal cancer, Gastric cancer, Metastasectomy, Metastasis, Oligometastasis, Stereotactic body radiotherapy note: © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). abstract: INTRODUCTION: The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD). METHODS: Guidelines were developed according to AGREE II and GRADE principles. Guidelines were based on a systematic review (OMEC-1), clinical case discussions (OMEC-2), and a Delphi consensus study (OMEC-3) by 49 European expert centers for esophagogastric cancer. OMEC identified patients for whom the term OMD is considered or could be considered. Disease-free interval (DFI) was defined as the time between primary tumor treatment and detection of OMD. RESULTS: Moderate to high quality of evidence was found (i.e. 1 randomized and 4 non-randomized phase II trials) resulting in moderate recommendations. OMD is considered in esophagogastric cancer patients with 1 organ with ≤ 3 metastases or 1 involved extra-regional lymph node station. In addition, OMD continues to be considered in patients with OMD without progression in number of metastases after systemic therapy. 18F-FDG PET/CT imaging is recommended for baseline staging and for restaging after systemic therapy when local treatment is considered. For patients with synchronous OMD or metachronous OMD and a DFI ≤ 2 years, recommended treatment consists of systemic therapy followed by restaging to assess suitability for local treatment. For patients with metachronous OMD and DFI > 2 years, upfront local treatment is additionally recommended. DISCUSSION: These multidisciplinary European clinical practice guidelines for the uniform definition, diagnosis and treatment of esophagogastric OMD can be used to standardize inclusion criteria in future clinical trials and to reduce variation in treatment. date: 2024-06 date_type: published publisher: Elsevier BV official_url: http://dx.doi.org/10.1016/j.ejca.2024.114062 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2271344 doi: 10.1016/j.ejca.2024.114062 medium: Print-Electronic pii: S0959-8049(24)00718-4 lyricists_name: Hawkins, Maria lyricists_id: MHAWK27 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: European Journal of Cancer volume: 204 article_number: 114062 event_location: England issn: 0959-8049 citation: Kroese, Tiuri E; Bronzwaer, Sebastiaan; van Rossum, Peter SN; Schoppman, Sebastian F; Deseyne, Pieter RAJ; van Cutsem, Eric; Haustermans, Karin; ... OMEC collaborators; + view all <#> Kroese, Tiuri E; Bronzwaer, Sebastiaan; van Rossum, Peter SN; Schoppman, Sebastian F; Deseyne, Pieter RAJ; van Cutsem, Eric; Haustermans, Karin; Nafteux, Philippe; Thomas, Melissa; Obermannova, Radka; Mortensen, Hanna R; Nordsmark, Marianne; Pfeiffer, Per; Elme, Anneli; Adenis, Antoine; Piessen, Guillaume; Bruns, Christiane J; Lordick, Florian; Gockel, Ines; Moehler, Markus; Gani, Cihan; Liakakos, Theodore; Reynolds, John V; Morganti, Alessio G; Rosati, Riccardo; Castoro, Carlo; Cellini, Francesco; D'Ugo, Domenico; Roviello, Franco; Bencivenga, Maria; de Manzoni, Giovanni; van Berge Henegouwen, Mark I; Hulshoff, Maarten CCM; van Dieren, Jolanda; Vollebergh, Marieke; van Sandick, Johanna W; Jeene, Paul; Muijs, Christel; Slingerland, Marije; Voncken, Francine EM; Hartgrink, Henk; Creemers, Geert-Jan; van der Sangen, Maurice JC; Nieuwenhuijzen, Grard AP; Berbee, Maaike; Verheij, Marcel; Wijnhoven, Bas; Beerepoot, Laurens V; Mohammad, Nadia Haj; Mook, Stella; Ruurda, Jelle P; Kolodziejczyk, Piotr; Polkowski, Wojciech P; Wyrwicz, Lucjan; Alsina, Maria; Tabernero, Josep; Pera, Manuel; Kanonnikoff, Tania F; Cervantes, Andrés; Nilsson, Magnus; Monig, Stefan; Wagner, Anna D; Guckenberger, Matthias; Griffiths, Ewen A; Smyth, Elizabeth; Hanna, George B; Markar, Sheraz; Chaudry, M Asif; Hawkins, Maria A; Cheong, Edward; van Laarhoven, Hanneke WM; van Hillegersberg, Richard; OMEC collaborators; - view fewer <#> (2024) European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4). European Journal of Cancer , 204 , Article 114062. 10.1016/j.ejca.2024.114062 <https://doi.org/10.1016/j.ejca.2024.114062>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10191815/1/1-s2.0-S0959804924007184-main.pdf