eprintid: 10191705
rev_number: 11
eprint_status: archive
userid: 699
dir: disk0/10/19/17/05
datestamp: 2024-05-09 13:24:59
lastmod: 2024-12-19 07:10:07
status_changed: 2024-05-09 13:24:59
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Nguyen, DTM
creators_name: Huynh, KDG
creators_name: Nguyen, TTD
creators_name: Huynh, VT
creators_name: Nguyen, PT
creators_name: Nguyen, LTB
title: Fabrication and characterization of polyvinyl alcohol/TiO2 membrane immersed in simulated body fluid for biomedical application
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D21
divisions: H10
keywords: PVA/TiO2, membrane, simulated body fluid, SBF, biomedical application
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: In this study, we synthesized hydroxyapatite (HA) on polyvinyl alcohol/TiO2 (PVA/TiO2) in which TiO2 was prepared by the sol-gel method. HA was formed by immersing the membrane in the simulated body fluid (SBF) solution. We improved the mechanical strength of the membranes by adding glutaraldehyde (GA) combining with heat treatment to cross-link the polymer network. In addition, the composition of TiO2 crystalline phase, TiO2 content in each membrane, and the duration of membrane immersion in SBF solution were investigated. The morphological structures of hydroxyapatite/polyvinyl alcohol/TiO2 (HA/PVA/TiO2) membranes were characterized by IR, SEM, and XRD. We confirmed that the HA formation depended on the TiO2 content and phase composition (rutile or anatase). Membranes containing TiO2 rutile-phase showed more pronounced HA formation than membranes containing TiO2 anatase-phase. The appearance of HA also depended on SBF immersion duration. Membranes soaked for 3 weeks showed significantly more HA formation than membranes soaked for 1 and 2 weeks. Furthermore, the number of cells in membranes soaked for 3 weeks was clearly higher than in other membranes. Finally, HA/PVA/TiO2 membranes containing 25 wt.% of TiO2 rutile-phase are biocompatible based on the number of viable cells and thus have the potential for biomedical application.
date: 2023-12-18
date_type: published
publisher: Wiley
official_url: http://dx.doi.org/10.1002/vjch.202300015
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2137639
doi: 10.1002/vjch.202300015
lyricists_name: Nguyen, Thuy Ba Linh
lyricists_id: LNGUY66
actors_name: Nguyen, Thuy Ba Linh
actors_id: LNGUY66
actors_role: owner
full_text_status: public
publication: Vietnam Journal of Chemistry
volume: 61
number: 6
pagerange: 741-754
issn: 2572-8288
citation:        Nguyen, DTM;    Huynh, KDG;    Nguyen, TTD;    Huynh, VT;    Nguyen, PT;    Nguyen, LTB;      (2023)    Fabrication and characterization of polyvinyl alcohol/TiO2 membrane immersed in simulated body fluid for biomedical application.                   Vietnam Journal of Chemistry , 61  (6)   pp. 741-754.    10.1002/vjch.202300015 <https://doi.org/10.1002/vjch.202300015>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10191705/3/Nguyen_Fabrication%20and%20Characterization%20of%20Polyvinyl%20Alcohol-%20TiO2%20Membrane%20immersed%20in%20Simulated%20Body%20Fluid%20for%20Biomedical%20Application.pdf