eprintid: 10191705 rev_number: 11 eprint_status: archive userid: 699 dir: disk0/10/19/17/05 datestamp: 2024-05-09 13:24:59 lastmod: 2024-12-19 07:10:07 status_changed: 2024-05-09 13:24:59 type: article metadata_visibility: show sword_depositor: 699 creators_name: Nguyen, DTM creators_name: Huynh, KDG creators_name: Nguyen, TTD creators_name: Huynh, VT creators_name: Nguyen, PT creators_name: Nguyen, LTB title: Fabrication and characterization of polyvinyl alcohol/TiO2 membrane immersed in simulated body fluid for biomedical application ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D21 divisions: H10 keywords: PVA/TiO2, membrane, simulated body fluid, SBF, biomedical application note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: In this study, we synthesized hydroxyapatite (HA) on polyvinyl alcohol/TiO2 (PVA/TiO2) in which TiO2 was prepared by the sol-gel method. HA was formed by immersing the membrane in the simulated body fluid (SBF) solution. We improved the mechanical strength of the membranes by adding glutaraldehyde (GA) combining with heat treatment to cross-link the polymer network. In addition, the composition of TiO2 crystalline phase, TiO2 content in each membrane, and the duration of membrane immersion in SBF solution were investigated. The morphological structures of hydroxyapatite/polyvinyl alcohol/TiO2 (HA/PVA/TiO2) membranes were characterized by IR, SEM, and XRD. We confirmed that the HA formation depended on the TiO2 content and phase composition (rutile or anatase). Membranes containing TiO2 rutile-phase showed more pronounced HA formation than membranes containing TiO2 anatase-phase. The appearance of HA also depended on SBF immersion duration. Membranes soaked for 3 weeks showed significantly more HA formation than membranes soaked for 1 and 2 weeks. Furthermore, the number of cells in membranes soaked for 3 weeks was clearly higher than in other membranes. Finally, HA/PVA/TiO2 membranes containing 25 wt.% of TiO2 rutile-phase are biocompatible based on the number of viable cells and thus have the potential for biomedical application. date: 2023-12-18 date_type: published publisher: Wiley official_url: http://dx.doi.org/10.1002/vjch.202300015 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2137639 doi: 10.1002/vjch.202300015 lyricists_name: Nguyen, Thuy Ba Linh lyricists_id: LNGUY66 actors_name: Nguyen, Thuy Ba Linh actors_id: LNGUY66 actors_role: owner full_text_status: public publication: Vietnam Journal of Chemistry volume: 61 number: 6 pagerange: 741-754 issn: 2572-8288 citation: Nguyen, DTM; Huynh, KDG; Nguyen, TTD; Huynh, VT; Nguyen, PT; Nguyen, LTB; (2023) Fabrication and characterization of polyvinyl alcohol/TiO2 membrane immersed in simulated body fluid for biomedical application. Vietnam Journal of Chemistry , 61 (6) pp. 741-754. 10.1002/vjch.202300015 <https://doi.org/10.1002/vjch.202300015>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10191705/3/Nguyen_Fabrication%20and%20Characterization%20of%20Polyvinyl%20Alcohol-%20TiO2%20Membrane%20immersed%20in%20Simulated%20Body%20Fluid%20for%20Biomedical%20Application.pdf