eprintid: 10191367
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/19/13/67
datestamp: 2024-04-26 11:01:40
lastmod: 2024-04-26 11:01:40
status_changed: 2024-04-26 11:01:40
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Lucatelli, Pierleone
creators_name: Ciaglia, Simone
creators_name: Rocco, Bianca
creators_name: De Rubeis, Gianluca
creators_name: Bolognesi, Guido
creators_name: Damato, Elio
creators_name: Corona, Mario
creators_name: Nardis, Pier Giorgio
creators_name: Cannavale, Alessandro
creators_name: Ricci, Paolo
creators_name: Catalano, Carlo
title: Two-dimensional perfusion angiography permits direct visualization of redistribution of flow in hepatocellular carcinoma during b-TACE
ispublished: inpress
divisions: UCL
divisions: B04
divisions: C06
divisions: F56
keywords: Balloon microcatheter, DEM-TACE, Hepatocellular carcinoma, In silico model, Two-dimensional perfusion angiographies, b-TACE
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abstract: OBJECTIVES: To demonstrate in vivo redistribution of the blood flow towards HCC's lesions by utilizing two-dimensional perfusion angiography in b-TACE procedures. MATERIAL AND METHODS: In total, 30 patients with 35 HCC nodules treated in the period between January 2019 and November 2021. For each patient, a post-processing software leading to a two-dimensional perfusion angiography was applied on each angiography performed via balloon microcatheter, before and after inflation. On the colour map obtained, reflecting the evolution of contrast intensity change over time, five regions of interests (ROIs) were assessed: one on the tumour (ROI-t), two in the immediate peritumoural healthy liver parenchyma (ROI-ihl) and two in the peripheral healthy liver parenchyma (ROI-phl). The results have been interpreted with a novel in silico model that simulates the hemodynamics of the hepatic arterial system. RESULTS: Among the ROIs drawn inside the same segment of target lesion, the time-to-peak of the ROI-t and of the ROI-ihl have a significantly higher mean value when the balloon was inflated compared with the ROIs obtained with deflated balloon (10.33 ± 3.66 s vs 8.87 ± 2.60 s (p = 0.015) for ROI-t; 10.50 ± 3.65 s vs 9.23 ± 2.70 s (p = 0.047) for ROI-ihl). The in silico model prediction time-to-peak delays when balloon was inflated, match with those observed in vivo. The numerical flow analysis shows how time-to-peak delays are caused by the obstruction of the balloon-occluded artery and the opening of intra-hepatic collateral. CONCLUSION: The measurements identify predictively the flow redistribution in the hepatic arteries during b-TACE, supporting a proper positioning of the balloon microcatheter.
date: 2024-04-18
date_type: published
publisher: Springer Science and Business Media LLC
official_url: https://doi.org/10.1007/s11547-024-01816-9
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2270483
doi: 10.1007/s11547-024-01816-9
pii: 10.1007/s11547-024-01816-9
lyricists_name: Bolognesi, Guido
lyricists_id: GBOLO69
actors_name: Bolognesi, Guido
actors_id: GBOLO69
actors_role: owner
full_text_status: public
publication: La radiologia medica
event_location: Italy
issn: 1826-6983
citation:        Lucatelli, Pierleone;    Ciaglia, Simone;    Rocco, Bianca;    De Rubeis, Gianluca;    Bolognesi, Guido;    Damato, Elio;    Corona, Mario;                 ... Catalano, Carlo; + view all <#>        Lucatelli, Pierleone;  Ciaglia, Simone;  Rocco, Bianca;  De Rubeis, Gianluca;  Bolognesi, Guido;  Damato, Elio;  Corona, Mario;  Nardis, Pier Giorgio;  Cannavale, Alessandro;  Ricci, Paolo;  Catalano, Carlo;   - view fewer <#>    (2024)    Two-dimensional perfusion angiography permits direct visualization of redistribution of flow in hepatocellular carcinoma during b-TACE.                   La radiologia medica        10.1007/s11547-024-01816-9 <https://doi.org/10.1007/s11547-024-01816-9>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10191367/1/Published.pdf