TY  - INPR
A1  - Lucatelli, Pierleone
A1  - Ciaglia, Simone
A1  - Rocco, Bianca
A1  - De Rubeis, Gianluca
A1  - Bolognesi, Guido
A1  - Damato, Elio
A1  - Corona, Mario
A1  - Nardis, Pier Giorgio
A1  - Cannavale, Alessandro
A1  - Ricci, Paolo
A1  - Catalano, Carlo
PB  - Springer Science and Business Media LLC
JF  - La radiologia medica
KW  - Balloon microcatheter
KW  -  DEM-TACE
KW  -  Hepatocellular carcinoma
KW  -  In silico model
KW  -  Two-dimensional perfusion angiographies
KW  -  b-TACE
N1  - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
N2  - OBJECTIVES: To demonstrate in vivo redistribution of the blood flow towards HCC's lesions by utilizing two-dimensional perfusion angiography in b-TACE procedures. MATERIAL AND METHODS: In total, 30 patients with 35 HCC nodules treated in the period between January 2019 and November 2021. For each patient, a post-processing software leading to a two-dimensional perfusion angiography was applied on each angiography performed via balloon microcatheter, before and after inflation. On the colour map obtained, reflecting the evolution of contrast intensity change over time, five regions of interests (ROIs) were assessed: one on the tumour (ROI-t), two in the immediate peritumoural healthy liver parenchyma (ROI-ihl) and two in the peripheral healthy liver parenchyma (ROI-phl). The results have been interpreted with a novel in silico model that simulates the hemodynamics of the hepatic arterial system. RESULTS: Among the ROIs drawn inside the same segment of target lesion, the time-to-peak of the ROI-t and of the ROI-ihl have a significantly higher mean value when the balloon was inflated compared with the ROIs obtained with deflated balloon (10.33?±?3.66 s vs 8.87?±?2.60 s (p?=?0.015) for ROI-t; 10.50?±?3.65 s vs 9.23?±?2.70 s (p?=?0.047) for ROI-ihl). The in silico model prediction time-to-peak delays when balloon was inflated, match with those observed in vivo. The numerical flow analysis shows how time-to-peak delays are caused by the obstruction of the balloon-occluded artery and the opening of intra-hepatic collateral. CONCLUSION: The measurements identify predictively the flow redistribution in the hepatic arteries during b-TACE, supporting a proper positioning of the balloon microcatheter.
ID  - discovery10191367
UR  - https://doi.org/10.1007/s11547-024-01816-9
SN  - 1826-6983
Y1  - 2024/04/18/
TI  - Two-dimensional perfusion angiography permits direct visualization of redistribution of flow in hepatocellular carcinoma during b-TACE
AV  - public
ER  -