%T Cognitive assessment during the phases of a spontaneous migraine: a prospective cohort study
%A JC Ray
%A D Darby
%A H Butzkueven
%A MS Matharu
%A EJ Hutton
%D 2024
%I Springer Science and Business Media LLC
%K Cognition, Cognitive impairment, Headache disorders, Migraine
%J Neurological Sciences
%L discovery10191334
%C Italy
%X INTRODUCTION: 
Cognitive symptoms are reported commonly throughout all phases of a migraine; however, there is a paucity of objective cognitive profiling. Previous studies have been limited by practice effect, and variable populations.

METHODS: 
Participants completed 1 month of daily testing with a computerised cognitive battery involving a simple reaction (SRT), choice reaction (CRT) and a working memory test (WM). Results were correlated with their diary to identify interictal scores, and scores during each phase of a migraine, and non-migraine headache days.


RESULTS: 
A total of 16 patients with episodic migraine participated. During the headache phase of a migraine, responses to SRT, CRT and WM tasks were significantly slower and less accurate than interictally. During the postdrome, WM task performance was slower and less accurate. Non-migraine headache days were not associated with significant change.

CONCLUSION: 
The headache and postdromal phase of a migraine day was associated with objective evidence of cognitive dysfunction in patients with episodic migraine.
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