%0 Book Section %A Khan, Abbas %A Asad, Muhammad %A Zolotarev, Alexander %A Roney, Caroline %A Mathur, Anthony %A Benning, Martin %A Slabaugh, Gregory %B Segmentation of the Aorta. Towards the Automatic Segmentation, Modeling, and Meshing of the Aortic Vessel Tree from Multicenter Acquisition: First Challenge %C Cham, Switzerland %D 2024 %E Pepe, Antonio %E Melito, Gian Marco %E Egger, Jan %F discovery:10191148 %I Springer Nature Switzerland %P 67-79 %S SEGA %T Misclassification Loss for Segmentation of the Aortic Vessel Tree %U https://discovery.ucl.ac.uk/id/eprint/10191148/ %V 14539 %X Common pixel-based loss functions for image segmentation struggle with the fine-scale structures often found in the aortic vessel tree. In this paper, we propose a Misclassification Loss (MC loss) function, which can effectively suppress false positives and rescue the false negatives. A differentiable eXclusive OR (XOR) operation is implemented to identify these false predictions, which are then minimized through a cross-entropy loss. The proposed MC loss helps the network achieve better performance by focusing on these difficult regions. On the Segmentation of the Aorta SEG.A. 2023 challenge, our method achieves a Dice score of 0.93 and a Hausdorff Distance (HD) of 3.50 mm on a 5-fold split of 56 training subjects. We participated in the SEG.A. 2023 challenge, and the proposed method ranks among the top-six approaches in the validation phase-1. The pre-trained models, source code, and implementation will be made public. %Z This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.