eprintid: 10190596 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/19/05/96 datestamp: 2024-04-12 12:30:18 lastmod: 2024-04-12 12:30:18 status_changed: 2024-04-12 12:30:18 type: article metadata_visibility: show sword_depositor: 699 creators_name: Brombal, Luca creators_name: Arfelli, Fulvia creators_name: Brun, Francesco creators_name: Di Trapani, Vittorio creators_name: Endrizzi, Marco creators_name: Menk, Ralf creators_name: Perion, Paola creators_name: Rigon, Luigi creators_name: Saccomano, Mara creators_name: Tromba, Giuliana creators_name: Olivo, Alessandro title: Edge-illumination spectral phase-contrast tomography ispublished: pub divisions: UCL divisions: B04 divisions: C05 divisions: F42 keywords: Edge illumination, Photon-counting detector, Spectral imaging, X-ray phase-contrast imaging, X-ray tomography note: Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. abstract: Following the rapid, but independent, diffusion of X-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination technique and a CdTe small-pixel (62 μm) spectral detector. A theoretical model is introduced, starting from a standard attenuation-based spectral decomposition and leading to spectral phase-contrast material decomposition. Each step of the model is followed by quantification of accuracy and sensitivity on experimental data of a test phantom containing different solutions with known concentrations. An example of a micro CT application (20 μm voxel size) on an iodine-perfusedex-vivomurine model is reported. 
The work demonstrates that spectral-phase contrast combines the advantages of spectral imaging, i.e. high-Z material discrimination capability, and phase-contrast imaging, i.e. soft tissue sensitivity, yielding simultaneously mass density maps of water, calcium, and iodine with an accuracy of 1.1%, 3.5%, and 1.9% (root mean square errors), respectively. Results also show a 9-fold increase in the signal-to-noise ratio of the water channel when compared to standard spectral decomposition. The application to the murine model revealed the potential of the technique in the simultaneous 3D visualization of soft tissue, bone, and vasculature. While being implemented by using a broad spectrum (pink beam) at a synchrotron radiation facility (Elettra, Trieste, Italy), the proposed experimental setup can be readily translated to compact laboratory systems including conventional X-ray tubes. date: 2024-04-07 date_type: published publisher: IOP Publishing official_url: http://dx.doi.org/10.1088/1361-6560/ad3328 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2260695 doi: 10.1088/1361-6560/ad3328 medium: Print-Electronic lyricists_name: Endrizzi, Marco lyricists_name: Olivo, Alessandro lyricists_id: MENDR57 lyricists_id: AOLIV86 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner funding_acknowledgements: P2022X5ALY [Ministero dell'Università e della Ricerca]; CiET1819/2/78 [Royal Academy of Engineering]; 18203/2016 [Commissione Scientifica Nazionale 5, Instituto Nazionale di Fisica Nucleare]; 22260/2020 [Commissione Scientifica Nazionale 5, Instituto Nazionale di Fisica Nucleare]; 221367/Z/20/Z [Wellcome Trust]; EP/T005408/1 [Engineering and Physical Sciences Research Council] full_text_status: public publication: Physics in Medicine & Biology volume: 69 number: 7 article_number: 075027 event_location: England issn: 0031-9155 citation: Brombal, Luca; Arfelli, Fulvia; Brun, Francesco; Di Trapani, Vittorio; Endrizzi, Marco; Menk, Ralf; Perion, Paola; ... Olivo, Alessandro; + view all <#> Brombal, Luca; Arfelli, Fulvia; Brun, Francesco; Di Trapani, Vittorio; Endrizzi, Marco; Menk, Ralf; Perion, Paola; Rigon, Luigi; Saccomano, Mara; Tromba, Giuliana; Olivo, Alessandro; - view fewer <#> (2024) Edge-illumination spectral phase-contrast tomography. Physics in Medicine & Biology , 69 (7) , Article 075027. 10.1088/1361-6560/ad3328 <https://doi.org/10.1088/1361-6560%2Fad3328>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10190596/1/Brombal_2024_Phys._Med._Biol._69_075027.pdf