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<https://discovery.ucl.ac.uk/id/eprint/10189770> <http://purl.org/dc/terms/title> "Development of Liquid-phase Transmission Electron Microscopy for the study of Proteins and Peptides"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10189770> <http://purl.org/ontology/bibo/abstract> "Liquid-phase transmission electron microscopy (LTEM) is a powerful technique to\r\nstudy the dynamics of molecular processes occurring in real-time. While the technique\r\nis becoming increasingly established in inorganic and metal-containing systems, the\r\nnext frontier of LTEM is the study of organic and biological material at the molecular\r\nlevel. In this project, I have worked on establishing LTEM as an effective imaging\r\nmethod to image biomolecules. To this end, I have imaged several control proteins\r\nincluding ferritin, β-galactosidase and apoferritin, with a variety of state-of-the-art\r\nLTEM systems. This project has proved highly challenging due to a combination of low\r\ninherent contrast, radiation sensitivity of the proteins and fast motion of the particles.\r\nAlongside the imaging of single proteins, an applied study of the aggregation of\r\namyloid-β peptide was also performed, yielding interesting data on the nucleation of\r\namyloid-β oligomers and fibrils, as well as demonstrations of phase separation. The\r\nwork on amyloid-β demonstrates the advantages of imaging large-scale systems with\r\nLTEM, despite the challenges associated with imaging individual proteins. Finally, this\r\nthesis also details the development of the Python library SimpliPyTEM to aid with\r\nimage processing and analysis of electron microscopy images and videos. Overall, the\r\nwork herein details the development of LTEM as a method for imaging biological\r\nmolecules, alongside a discussion of the limitations and future of the technique."^^<http://www.w3.org/2001/XMLSchema#string> .
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