eprintid: 10189357
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/18/93/57
datestamp: 2024-03-19 13:54:45
lastmod: 2024-03-19 13:54:45
status_changed: 2024-03-19 13:54:45
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Han, Kunyuan
creators_name: Chen, Jishizhan
creators_name: Han, Qinglin
creators_name: Sun, Lei
creators_name: Dong, Xieping
creators_name: Shi, Gengqiang
creators_name: Yang, Runhuai
creators_name: Wei, Wenqing
creators_name: Cheng, Yunzhang
title: Nanoclay Hydrogel Microspheres with a Sandwich-Like Structure for Complex Tissue Infection Treatment
ispublished: pub
divisions: UCL
divisions: B04
divisions: C05
divisions: F45
keywords: Bioantimicrobial materials, nanobactericidal hydrogel microspheres, nanoclays, sandwich-like structures, tissue infections
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Addressing complex tissue infections remains a challenging task because of the lack of effective means, and the limitations of traditional bioantimicrobial materials in single-application scenarios hinder their utility for complex infection sites. Hence, the development of a bioantimicrobial material with broad applicability and potent bactericidal activity is necessary to treat such infections. In this study, a layered lithium magnesium silicate nanoclay (LMS) is used to construct a nanobactericidal platform. This platform exhibits a sandwich-like structure, which is achieved through copper ion modification using a dopamine-mediated metallophenolic network. Moreover, the nanoclay is encapsulated within gelatin methacryloyl (GelMA) hydrogel microspheres for the treatment of complex tissue infections. The results demonstrate that the sandwich-like micro- and nanobactericidal hydrogel microspheres effectively eradicated Staphylococcus aureus (S. aureus) while exhibiting excellent biocompatibility with bone marrow-derived mesenchymal stem cells (BMSCs) and human umbilical vein endothelial cells (HUVECs). Furthermore, the hydrogel microspheres upregulated the expression levels of osteogenic differentiation and angiogenesis-related genes in these cells. In vivo experiments validated the efficacy of sandwich-like micro- and nanobactericidal hydrogel microspheres when injected into deep infected tissues, effectively eliminating bacteria and promoting robust vascular regeneration and tissue repair. Therefore, these innovative sandwich-like micro- and nanobacteriostatic hydrogel microspheres show great potential for treating complex tissue infections.
date: 2024-03-11
date_type: published
publisher: Wiley-VCH Verlag
official_url: https://doi.org/10.1002/mabi.202400027
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2256697
doi: 10.1002/mabi.202400027
medium: Print-Electronic
lyricists_name: Chen, Jishizhan
lyricists_id: JCHEI07
actors_name: Zahnhausen-Stuber, Petra
actors_id: PMZAH20
actors_role: owner
full_text_status: restricted
publication: Macromolecular Bioscience
event_location: Germany
issn: 1616-5187
citation:        Han, Kunyuan;    Chen, Jishizhan;    Han, Qinglin;    Sun, Lei;    Dong, Xieping;    Shi, Gengqiang;    Yang, Runhuai;         ... Cheng, Yunzhang; + view all <#>        Han, Kunyuan;  Chen, Jishizhan;  Han, Qinglin;  Sun, Lei;  Dong, Xieping;  Shi, Gengqiang;  Yang, Runhuai;  Wei, Wenqing;  Cheng, Yunzhang;   - view fewer <#>    (2024)    Nanoclay Hydrogel Microspheres with a Sandwich-Like Structure for Complex Tissue Infection Treatment.                   Macromolecular Bioscience        10.1002/mabi.202400027 <https://doi.org/10.1002/mabi.202400027>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10189357/1/Chen_Nanoclay%20Hydrogel%20Microspheres%20with%20a%20Sandwich-Like%20Structure%20for%20Complex%20Tissue%20Infection%20Treatment.pdf