TY  - JOUR
TI  - Proneural Transcription Factors Regulate Different Steps of Cortical Neuron Migration through Rnd-Mediated Inhibition of RhoA Signaling
EP  - 1084
AV  - public
Y1  - 2011/03/24/
ID  - discovery10189187
N2  - Little is known of the intracellular machinery that controls the motility of newborn neurons. We have previously shown that the proneural protein Neurog2 promotes the migration of nascent cortical neurons by inducing the expression of the atypical Rho GTPase Rnd2. Here, we show that another proneural factor, Ascl1, promotes neuronal migration in the cortex through direct regulation of a second Rnd family member, Rnd3. Both Rnd2 and Rnd3 promote neuronal migration by inhibiting RhoA signaling, but they control distinct steps of the migratory process, multipolar to bipolar transition in the intermediate zone and locomotion in the cortical plate, respectively. Interestingly, these divergent functions directly result from the distinct subcellular distributions of the two Rnd proteins. Because Rnd proteins also regulate progenitor divisions and neurite outgrowth, we propose that proneural factors, through spatiotemporal regulation of Rnd proteins, integrate the process of neuronal migration with other events in the neurogenic program. © 2011 Elsevier Inc.
PB  - CELL PRESS
SP  - 1069
VL  - 69
N1  - This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
IS  - 6
SN  - 0896-6273
UR  - https://doi.org/10.1016/j.neuron.2011.02.018
JF  - Neuron
A1  - Pacary, Emilie
A1  - Heng, Julian
A1  - Azzarelli, Roberta
A1  - Riou, Philippe
A1  - Castro, Diogo
A1  - Lebel-Potter, Melanie
A1  - Parras, Carlos
A1  - Bell, Donald M
A1  - Ridley, Anne J
A1  - Parsons, Maddy
A1  - Guillemot, Francois
ER  -